Pan-cancer landscape of homologous recombination deficiency

Homologous recombination deficiency (HRD) results in impaired double strand break repair and is a frequent driver of tumorigenesis. Here, we develop a genome-wide mutational scar-based pan-cancer Classifier of HOmologous Recombination Deficiency (CHORD) that can discriminate BRCA1 - and BRCA2 -subtypes. Analysis of a metastatic ( n = 3,504) and primary ( n = 1,854) pan-cancer cohort reveals that HRD is most frequent in ovarian and breast cancer,...