“Modeling−Prediction” Strategy for Deep Profiling of Lysophosphatidic Acids by Liquid Chromatography−Mass Spectrometry: Exploration Biomarkers of Breast Cancer

Lysophosphatidic acids (LPAs) are important bioactive phospholipids consisting of various species involved in a wide array of physiological and pathological processes. However, LPAs were rarely identified in untargeted lipidomics studies because of the incompatibility with analytical methods. Moreover, in targeted studies, the coverages of LPAs remained unsatisfactorily low due to the limitation of reference standards. Herein, a...