Qing Li
Shenyang Pharmaceutical University
AnalytePharmacokineticsAnalytical chemistryDetection limitMass spectrometryHigh-performance liquid chromatographyChemistryTraditional Chinese medicineDecoctionMetabolomicsCalibration curveOral administrationFormic acidTandem mass spectrometryElectrospray ionizationChromatographyExtraction (chemistry)Liquid chromatography–mass spectrometrySelected reaction monitoringMedicinePharmacology
144Publications
21H-index
1,778Citations
Publications 143
Newest
#1Wanjun Li (SPU: Shenyang Pharmaceutical University)
#2Song Cang (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Ran Liu (SPU: Shenyang Pharmaceutical University)H-Index: 14
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Hydroxypropyl-β-cyclodextrin, possessing higher water solubility and lower hemolytic, was widely used as solubilizer and excipient. It had also been reported that hydroxypropyl-β-cyclodextrin has the activity of regulating lipid homeostatic. In order to further understand the metabolism, the primary focus was to establish a quantitative method for hydroxypropyl-β-cyclodextrin. The analytes were extracted from plasma by protein precipitation with methanol, and then carried out on Waters CORTECS T...
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#1Chunyu YuH-Index: 2
#2Qian ZhangH-Index: 7
Last. Qing LiH-Index: 21
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Abstract LC-MS-based metabolomics offers the potential of discovering biomarkers and exploring the mechanisms of underlying diseases. However, given the enormous polarity difference between metabolites, simultaneous across-polarity quantification for broad metabolome coverage has still been challenged by limited sample preparation methods and other hurdles. Herein, we proposed a consecutive extraction strategy based on nanoconfined liquid phase nanoextraction (NLPNE) technique. By modulating the...
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#1Jiao HeH-Index: 4
#2Qian ZhangH-Index: 7
Last. Qing Li (SPU: Shenyang Pharmaceutical University)H-Index: 21
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C. morifolium flower and C. indicum flower are two closely related herbal species with similar morphological and microscopic characteristics but are discriminated in edible and medicinal purpose. However, there is no effective approach to distinguish the two herbs. A novel workflow for quickly differentiating C. morifolium flower and C. indicum flower was developed. Firstly, the difference in anti-inflammatory effects for C. morifolium flower and C. indicum flower was characterized using lipopol...
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#1Zhenduo Shen (SPU: Shenyang Pharmaceutical University)
Last. Qing Li (SPU: Shenyang Pharmaceutical University)H-Index: 21
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Abstract Ziv-aflibercept (aflibercept) is a recombinant fusion protein which combines the portions of human vascular endothelial growth factor receptors extracellular domains fused to the Fc portion of human IgG1. It is a highly sialylated glycoprotein with 5 N-glycosylation sites. In this study, a comprehensive strategy for comparability study of the complex glycosylation was developed between aflibercept and the biosimilar candidate including the investigations on N-glycosylation sites, site o...
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#1Yiwen Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 5
#2Saiyu Li (SPU: Shenyang Pharmaceutical University)
Last. Qing Li (SPU: Shenyang Pharmaceutical University)H-Index: 21
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Abstract Asari Radix et Rhizoma (Asarum), a traditional Chinese medicine (TCM), has been applied in clinical generally. However, due to the lack of valid methods for Asarum quality control, inhomogenous quality and therapy issues have become severe with each passing day. In this study, we aimed to establish a comprehensive multi-system to explore the quality control markers underlying pharmaceutical effects based on chemometrics analysis on the total ingredients of Asarum. In brief, DNA barcodin...
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#1Qian Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 7
#2Xiao Yang (SPU: Shenyang Pharmaceutical University)H-Index: 3
Last. Qing Li (SPU: Shenyang Pharmaceutical University)H-Index: 21
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Lysophosphatidic acids (LPAs) are important bioactive phospholipids consisting of various species involved in a wide array of physiological and pathological processes. However, LPAs were rarely identified in untargeted lipidomics studies because of the incompatibility with analytical methods. Moreover, in targeted studies, the coverages of LPAs remained unsatisfactorily low due to the limitation of reference standards. Herein, a "modeling-prediction" workflow for deep profiling of LPAs by liquid...
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#1Tianyang Wang (SPU: Shenyang Pharmaceutical University)H-Index: 6
#2Song Lin (Qiqihar Medical University)H-Index: 3
Last. Kaishun Bi (SPU: Shenyang Pharmaceutical University)H-Index: 32
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Abstract Background Previously, we have investigated the therapeutic mechanism of Qingzao Jiufei Decoction (QZJFD), a Chinese classic prescription, on acute lung injury (ALI), however, which remained to be further clarified together with the underlying efficacy related compounds for quality markers (Q-markers). Hypothesis/Purpose To explore Q-markers of QZJFD on ALI by integrating a stepwise multi-system with ‘network pharmacology-metabolomics- pharmacokinetic (PK)/ pharmacodynamic (PD) modeling...
1 CitationsSource
#1Kewen DingH-Index: 2
#1Ding Kewen (Shenyang)
Last. Bi Kaishun (Shenyang)
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: A new triterpenoid saponin (1), 3-O-[β-D-glucopyranosyl(1→6)]-(2'-angeloyl)-β-D-glucopyranosyl-28-O-β-D-glucopyranosyl(1→6)[α-L-rhamnopyranosyl(1→2)-β-D-glucopyranosyl]-21-O-acetyl-16-deoxybarringtogenol C, together with four known saponins (2 ∼ 5) were isolated from the husks of Xanthoceras sorbifolium Bunge. Their structures were characterized by HR-ESI-MS, 1D-NMR, 2D-NMR spectra and chemical methods. Compound 1 exhibited excellent neuroprotection on PC12 cells injury induced by Aβ25-35 at t...
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#1Weiwei Rong (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Zheng Sun (SPU: Shenyang Pharmaceutical University)H-Index: 2
Last. Kaishun Bi (SPU: Shenyang Pharmaceutical University)H-Index: 32
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#1Qi Tang (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Song Cang (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Ran Liu (SPU: Shenyang Pharmaceutical University)H-Index: 14
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Colorectal cancer (CRC) is one of the most serious complications of ulcerative colitis (UC). Altered gut microbiota is implicated in the development of CRC and metabolic perturbations are often associated with changes in the gut microbiome composition. Given the links between gut microbiome and the metabolic profiles in the body, an approach involving ultra-high-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UHPLC-Q-TOF...
1 CitationsSource