Journal of Chromatography A
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#1Peng Li (BMS: Bristol-Myers Squibb)H-Index: 7
#2Dauh-Rurng Wu (BMS: Bristol-Myers Squibb)H-Index: 12
Last. Arvind Mathur (BMS: Bristol-Myers Squibb)H-Index: 22
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Abstract null null BMS-962212, a parenteral Factor XIa inhibitor, was scaled-up for toxicity studies. Two steps of supercritical fluid chromatography (SFC) were developed for the chiral resolution of the penultimate and achiral purification of final active pharmaceutical ingredient (API), BMS-962212. A robust SFC process using Chiralcel OD-H with methanol-acetonitrile as modifier in CO2 was established to achieve a stable and uninterrupted operation with reduced mobile phase viscosity and system...
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#1Szabolcs Horváth (University of Pannonia)H-Index: 1
#2Fabrice Gritti (Waters Corporation)H-Index: 67
Last. Krisztián Horváth (University of Pannonia)H-Index: 16
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Abstract null null Modern analytical applications of liquid chromatography require more and more efficient columns. In this work, the possibility of utilizing particle size gradient in the chromatographic column was studied by a theoretical approach. In the course of our work three different scenarios of particle size gradients were considered with different shapes (linear, convex and concave). The evolution of bandwidth inside the column was plotted for each scenario. As a reference point, the ...
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#1Abhijit Tarafder (Amgen)H-Index: 2
#2Malik McKnight (Amgen)
Last. Larry Miller (Amgen)H-Index: 17
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Abstract null null Preparative chiral separations are carried out using chiral stationary-phases (CSP) employing isocratic composition mode to take advantage of stacking multiple injections within a single continuous operation. Development of the separation method, however, is not conducted directly in the preparative systems. Chromatographic systems at analytical scale are set up to screen multiple CSPs with various mobile-phases (MP) to detect a suitable CSP-MP combination. For faster method s...
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#1Eleonora Oliva (University of Teramo)H-Index: 1
#2Eduardo Viteritti (University of Teramo)
Last. Dario Compagnone (University of Teramo)H-Index: 38
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Abstract null null In this work two different acquisition approaches were used for the quantification and/or tentative identification of phenolic compounds (PCs) in plant matrices by HPLC-MS/MS. A targeted approach, based on MRM acquisition mode, was used for the identification and quantification of a list of target analytes by comparison with standards; a semi-targeted approach was also developed by the precursor ion scan and neutral loss for the tentative identification of compounds not includ...
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#1Harini Narayanan (ETH Zurich)H-Index: 6
#2Tobias Seidler (ETH Zurich)
Last. Alessandro ButtéH-Index: 23
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Abstract The biopharmaceutical industries are continuously faced with the pressure to reduce the development costs and accelerate development time scales. The traditional approach of heuristic-based or platform process-based optimization is soon getting obsolete, and more generalized tools for process development and optimization are required to keep pace with the emerging trends. Thus, advanced model-based methods that can reduce the can ensure accelerated development of robust processes with m...
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Last. Jennifer P. Pascali (UNIPD: University of Padua)H-Index: 1
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Abstract The potentially carcinogenic process contaminant 3- and 2-monochloropropanediol esters (2-MCPD and 3-MCPD esters) and glycidyl esters (GEs) are under study in refined oils and foodstuffs. Legislation set recommended total daily intake (TDI) for 3-MCPD of 0.8µg/kg and as low as reasonably achievable (ALARA) for glycidol. Usually, the so far adopted method for the determination of these contaminants relay on numerous and time-consuming steps for sample preparation (AOCS methods) and on GC...
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ABSTRACT A new green method for trace level quantification of four herbicides, glyphosate (GLYP), glufosinate (GLUF), and their main metabolites, aminomethylphosphonic acid (AMPA) and 3-(methyl-phosphinico)-propionic acid (MPPA), was developed. The purification step without any derivatization was conducted by solid-phase extraction using Chelex-100 resin in the Fe (III) form, followed by elution with 5% NH4OH. The four analytes were quantified by ultra-high-performance liquid chromatography coup...
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#1Keyu Feng (Tianjin University of Traditional Chinese Medicine)H-Index: 1
#2Simiao Wang (Tianjin University of Traditional Chinese Medicine)H-Index: 1
Last. Wenzhi Yang (Tianjin University of Traditional Chinese Medicine)H-Index: 5
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Abstract Herbs represent complex chemical systems involving various primary and secondary metabolites that are featured by large spans of acid-base property, polarity, molecular mass, and content, etc., which thus poses great challenges to characterize the metabolites contained. Here, the combination of multiple-mechanism chromatography coupled with improved data-dependent-MS2 acquisition (DDA-MS2) is presented as a strategy to support the deep metabolites characterization. Targeting Uncaria ses...
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Abstract Improved closed-loop recycling counter-current chromatography (CLR CCC) with a two-phase solvent system composed of n-hexane–acetonitrile (1:1, v/v) was developed for separation, purification and preparation of cyclosporin D from the crude extract of fungus Hypoxylon Spp. (sj18). 28 mg cyclosporin D was successfully purified from 300 mg crude extract sample. The purity was 95.2% after five cycles, determined by HPLC. The structure of cyclosporin D was identified and assigned by 1H NMR, ...
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#1Sandya BeeramH-Index: 8
#2Chenhua ZhangH-Index: 6
Last. David S. HageH-Index: 63
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Many drugs bind to serum transport proteins, which can affect both drug distribution and activity in the body. α1-Acid glycoprotein (AGP) is a key transport protein for basic and neutral drugs. Both elevated levels and altered glycosylation patterns of AGP have been seen in clinical conditions such as systemic lupus erythematosus (SLE). This study developed, optimized, and used the method of ultrafast affinity extraction (UAE) to examine whether these changes in AGP are associated with changes i...
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