Coadministration of metformin prevents olanzapine-induced metabolic dysfunction and regulates the gut-liver axis in rats

Olanzapine is widely prescribed for patients with mental disorders; however, it may induce metabolic dysfunction. Metformin is an efficient adjuvant for preventing olanzapine-induced metabolic dysfunction in clinical practice. Although the mechanism of how metformin prevents this metabolic dysfunction remains unknown, changes in the gut-liver axis are considered a potential explanation. Forty-eight male rats were gavaged with olanzapine and/or...