Psychopharmacology
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#1Lindsey R. Hammerslag (UK: University of Kentucky)H-Index: 6
#2Emily D. Denehy (UK: University of Kentucky)H-Index: 4
Last. Michael T. Bardo (UK: University of Kentucky)H-Index: 53
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RATIONALE Opioid use disorder (OUD) is highly comorbid with stress-related disorders, and stress can serve as a trigger for reinstatement of drug seeking. Glucocorticoid receptor (GR) antagonists such as mifepristone (RU-486) may be effective against stress-induced drug seeking. In the current study, PT150 (formerly ORG-34517), a more selective GR antagonist, was tested using two models of stress-induced drug seeking, namely footshock and yohimbine. METHODS Adult male and female Sprague-Dawley r...
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#1Ilya D. Ionov (RAS: Russian Academy of Sciences)H-Index: 5
Last. Nicholas N. SevertsevH-Index: 2
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RATIONALE Recently, it was found that cyclosomatostatin-induced catalepsy in middle-aged rats is accompanied by neuronal hypoactivation in the lateral entorhinal cortex (LEntCx); this hypoactivation was reversed by systemic administration of nicotine combined with diphenhydramine. These findings suggest the ability of nicotine to regulate catalepsy and the involvement of the LEntCx in this nicotine effect. OBJECTIVES The study was aimed to assess whether nicotine alone influences catalepsy when ...
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#1Ye Yang (CSU: Central South University)H-Index: 4
#2Yujun Long (CSU: Central South University)H-Index: 2
Last. Jingping Zhao (CSU: Central South University)H-Index: 38
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Rationale Gut microbiota plays an important role in host metabolism. Antipsychotic drugs can result in metabolic abnormalities. Probiotics may ameliorate the antipsychotic drug-induced metabolic abnormalities by regulating gut microbiota. Objective To determine whether Bifidobacterium intervention can ameliorate olanzapine-induced weight increase. Methods Enrolled patients were assigned to either the olanzapine or olanzapine plus Bifidobacterium group. The following were assessed: body weight, b...
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#1Mark D. Tricklebank ('KCL': King's College London)H-Index: 29
#2Trevor W. Robbins (University of Cambridge)H-Index: 214
Last. Erik H. F. Wong (UBC: University of British Columbia)H-Index: 1
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#1Mahnaz Bayat (Shiraz University of Medical Sciences)H-Index: 3
#2Kristi A. Kohlmeier (UCPH: University of Copenhagen)H-Index: 17
Last. Mohammad Shabani (KMU: Kerman Medical University)H-Index: 23
view all 8 authors...
Environmental enrichment (EE) has been shown in old rats to improve learning and memory. Vitamin D (VitD) has also been shown to modulate age-related, cognitive dysfunction. As both EE and VitD could work to improve cognition via enhancement of neurotrophic factors, their effects might occlude one another. Therefore, a clinically relevant question is whether noted cognition-promoting effects of EE and VitD can co-occur. Aged rats were housed for 6 weeks in one of three housing conditions: enviro...
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#1Marion A. Coe (UK: University of Kentucky)H-Index: 6
#2Michelle R. Lofwall (UK: University of Kentucky)H-Index: 26
Last. Sharon L. WalshH-Index: 43
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Preclinical studies demonstrate that the NK1 receptor is involved in opioid reinforcement and withdrawal expression. Few studies have examined the impact of treatment with NK1 antagonists on opioid response in humans. To explore the potential for a selective NK1 antagonist, tradipitant, to attenuate the abuse liability and reinforcing and analgesic effects of oxycodone in opioid-experienced individuals. Participants with recreational opioid use, but without opioid physical dependence, were enrol...
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#1Jillian M. Rung (UF: University of Florida)H-Index: 1
#2Marilyn Horta (UF: University of Florida)H-Index: 3
Last. Natalie C. Ebner (UF: University of Florida)H-Index: 23
view all 13 authors...
Most studies evaluating the safety and tolerability of intranasal oxytocin (OT) have not reported consistent adverse events (AEs), but they have largely focused on young men and single-dose administration. Thus, it is unclear whether these findings translate to older individuals and with longer administration periods. Extending previous work, this study investigated the safety and tolerability of chronic intranasal OT in generally healthy older men. Data were from a randomized, placebo (P)-contr...
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#1Maggie M. Sweitzer (Duke University)H-Index: 17
#2Lauren R. Pacek (Duke University)H-Index: 20
Last. F. Joseph McClernon (Duke University)H-Index: 39
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Reducing nicotine content in cigarettes to ≤ 2.4 mg per g of tobacco [mg/g] reduces smoking behavior and toxicant exposure among adult daily smokers. However, cigarettes with similar nicotine content could support continued experimentation and smoking progression among young adults who smoke infrequently. This study evaluated the threshold for nicotine in cigarettes that produces reactions associated with smoking progression in a sample of young adults who smoke infrequently. Young adults (n = 8...
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#1Jay-Shake Li (CCU: National Chung Cheng University)H-Index: 7
#2Shan-Sung Yang (CCU: National Chung Cheng University)
Last. Claudia Mattern (NSU: Nova Southeastern University)H-Index: 19
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Studies on the attention-deficit/hyperactivity disorder (ADHD) have concluded that the disorder might be caused by a deficit in the inhibitory control of executive functions because of dopamine hypofunction. Recently, the intranasal route has emerged as an effective alternative means for sending dopamine directly to the brain. However, whether the treatment can ameliorate the deficits of inhibitory control in ADHD remains unknown. Investigating the effects of acute intranasal dopamine (IN-DA) on...
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#1Tiffany Lago (NIH: National Institutes of Health)H-Index: 5
Last. Christian Grillon (NIH: National Institutes of Health)H-Index: 78
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RATIONALE Arginine vasopressin (AVP) is a neuropeptide that modulates both physiological and emotional responses to threat. Until recently, drugs that target vasopressin receptors (V1a) in the human central nervous system were unavailable. The development of a novel V1a receptor antagonist, SRX246, permits the experimental validation of vasopressin's role in the regulation of anxiety and fear in humans. OBJECTIVES Here, we examined the effects of SRX246 in a proof-of-concept translational paradi...
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