Psychopharmacology
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#1E.E. Edem (ABUAD: Afe Babalola University)H-Index: 1
#2Collins-Kevin Chukwudi Anyanwu (ABUAD: Afe Babalola University)
Last. Linus Anderson Enye (ABUAD: Afe Babalola University)H-Index: 3
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Major depressive disorder (MDD) is a serious mental disorder with influence across the functional systems of the body. The pathogenesis of MDD has been known to involve the alteration of normal body functions responsible for the normal inflammation processes within the CNS; this along with other effects results in the depreciation of the sensorimotor performance of the body. Ketamine hydrochloride, a novel antidepressant agent, has been used as a therapeutic agent to treat MDD with its efficacy ...
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#2Serena Civardi (UNIPV: University of Pavia)H-Index: 1
Last. Natascia Brondino (UNIPV: University of Pavia)H-Index: 21
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Rationale null The use of intravenous valproate is not approved for clinical practice in psychiatry. Literature data pointed out for a potential usefulness of this route of administration for valproate, but there is no actual consensus. null Objectives null The aim of the present systematic review is to assess the effectiveness of intravenous valproate in agitation as well as general safety. null Methods null A systematic review of studies evaluating the use of intravenous valproate in agitation...
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#2Carine Kolly (Novartis)H-Index: 5
Last. Kasra Shakeri-Nejad (Novartis)H-Index: 7
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Abuse and misuse of prescription drugs remains an ongoing concern in the USA and worldwide; thus, all centrally active new drugs must be assessed for abuse and dependence potential. Sphingosine-1-phosphate (S1P) receptor modulators are used primarily in the treatment of multiple sclerosis. Among the new S1P receptor modulators, siponimod, ozanimod, and ponesimod have recently been approved in the USA, European Union (EU), and other countries. This review of literature and other public data has b...
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#1Oliver Härmson (University of Oxford)
#2Laura L Grima (HHMI: Howard Hughes Medical Institute)H-Index: 3
Last. Mark E. Walton (University of Oxford)H-Index: 40
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The serotonin (5-HT) system, particularly the 5-HT2C receptor, has consistently been implicated in behavioural control. However, while some studies have focused on the role 5-HT2C receptors play in regulating motivation to work for reward, others have highlighted its importance in response restraint. To date, it is unclear how 5-HT transmission at this receptor regulates the balance of response invigoration and restraint in anticipation of future reward. In addition, it remains to be established...
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#1Rituparna Maiti (All India Institute of Medical Sciences)H-Index: 11
#2Archana Mishra (All India Institute of Medical Sciences)H-Index: 5
Last. Monalisa Jena (All India Institute of Medical Sciences)H-Index: 6
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Rationale null Mitochondrial dysfunctions have emerged as new biological hypothesis and therapeutic target for bipolar disorder. This network meta-analysis has been done to evaluate the comparative efficacy of mitochondrial agents in bipolar depression. null Methods null After a comprehensive literature search on PubMed/MEDLINE, Cochrane databases, and International Trials Registry Platform, efficacy data were extracted from 15 randomized controlled trials. Random-effects meta-analysis was done ...
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#1Alexander Kaltenboeck (University of Oxford)H-Index: 5
#2Tereza Ruzickova (University of Oxford)
Last. Catherine J. Harmer (Oxford Health NHS Foundation Trust)H-Index: 75
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Rationale null Bright light treatment (BLT) is an efficacious antidepressant intervention, but its mechanism of action is not well understood. Antidepressant drugs acutely affect how emotional information is processed, pushing the brain to prioritise positive relative to negative input. Whether BLT could have a similar effect is not known to date. null Objective null To test whether BLT acutely influences emotional information processing similar to antidepressant drugs, using an established heal...
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#1Shuo-Fu ChenH-Index: 2
Last. Ruey-Ming LiaoH-Index: 2
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In human beings and experimental animals, maladaptive impulsivity is manifested by the acute injection of psychostimulants, such as amphetamine. Cannabinoid CB1 receptors have been implicated in the regulation of stimulant-induced impulsive action, but the role of CB1 receptors in timing-related impulsive action by amphetamine remains unknown. Male rats were used in evaluating the effects of CB1 receptor antagonist and agonist (SR141716A and WIN55,212–2, respectively) systemically administered i...
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#1Lauren Kuhns (UvA: University of Amsterdam)H-Index: 4
#2Emese Kroon (UvA: University of Amsterdam)H-Index: 4
Last. Janna Cousijn (UvA: University of Amsterdam)H-Index: 24
view all 4 authors...
Rationale null Cannabis use among people with mood disorders increased in recent years. While comorbidity between cannabis use, cannabis use disorder (CUD), and mood disorders is high, the underlying mechanisms remain unclear. null Objectives null We aimed to evaluate (1) the epidemiological evidence for an association between cannabis use, CUD, and mood disorders; (2) prospective longitudinal, genetic, and neurocognitive evidence of underlying mechanisms; and (3) prognosis and treatment options...
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#1Lieke Hofmans (Radboud University Nijmegen)H-Index: 3
#2Andrew Westbrook (Radboud University Nijmegen)H-Index: 11
Last. Roshan Cools (Radboud University Nijmegen)H-Index: 66
view all 6 authors...
RATIONALE We constantly need to decide not only which actions to perform, but also how vigorously to perform them. In agreement with an earlier theoretical model, it has been shown that a significant portion of the variance in our action vigor can be explained by the average rate of rewards received for that action. Moreover, this invigorating effect of average reward rate was shown to vary with within-subject changes in dopamine, both in human individuals and experimental rodents. OBJECTIVES He...
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#1Joanna Kuc (Imperial College London)
#2Hannes Kettner (Imperial College London)H-Index: 7
Last. Robin L. Carhart-Harris (Imperial College London)H-Index: 53
view all 8 authors...
Classic psychedelics are currently being studied as novel treatments for a range of psychiatric disorders. However, research on how psychedelics interact with other psychoactive substances remains scarce. The current study aimed to explore the subjective effects of psychedelics when used alongside cannabis. Participants (n = 321) completed a set of online surveys at 2 time points: 7 days before, and 1 day after a planned experience with a serotonergic psychedelic. The collected data included dem...
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