Zhao-Qian Liu
Central South University
GenePharmacokineticsCancerInternal medicineEndocrinologyGenotypeOncologySingle-nucleotide polymorphismAlleleChemistryImmunologyLung cancerChemotherapyCancer researchPharmacogeneticsBioinformaticsMedicineBiologyGastroenterologyPharmacology
313Publications
49H-index
5,732Citations
Publications 306
Newest
#1Tao Zhu (CSU: Central South University)H-Index: 13
#2Juyan Zheng (CSU: Central South University)H-Index: 1
Last. Zhao-Qian Liu (CSU: Central South University)H-Index: 49
view all 10 authors...
Cancer stem cells (CSCs) are a major cause of tumor treatment resistance, relapse and metastasis. Cancer cells exhibit reprogrammed metabolism characterized by aerobic glycolysis, which is also critical for sustaining cancer stemness. However, regulation of cancer cell metabolism rewiring and stemness is not completely understood. Here, we report that ETV4 is a key transcription factor in regulating glycolytic gene expression. ETV4 loss significantly inhibits the expression of HK2, LDHA as well ...
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#1Huixiang Tian (CSU: Central South University)
#2Yue-Qin Li (CSU: Central South University)H-Index: 3
Last. Xiang-Ping Li (CSU: Central South University)H-Index: 16
view all 8 authors...
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#1Juan Chen (CSU: Central South University)H-Index: 13
#2Jun-Yan Liu (University of South China)H-Index: 5
Last. Zhao-Qian Liu (CSU: Central South University)H-Index: 49
view all 15 authors...
Abstract Background Anthracycline are inhibitors of topoisomerase II leading to DNA double strand breaks, and it is widely used for treatment of breast cancer. eIF3a is the largest subunit of eukaryotic translation initiation factor 3 (eIF3) and highly expressed in breast cancer. In this study, we investigated the role of eIF3a in DSB DNA repair and the response of breast cancer patients to anthracycline-based chemotherapy. Methods MTT assay was used to detect anthracycline sensitivity in cell l...
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#1Pan Xie (CSU: Central South University)H-Index: 4
#2Fu-Qiang Yuan (CSU: Central South University)H-Index: 1
Last. Zhao-Qian Liu (CSU: Central South University)H-Index: 49
view all 7 authors...
Background: DCBLD2 is highly expressed in various cancers, including colorectal cancer. DCBLD2 overexpression promotes tumor occurrence, development, and metastasis. However, DCBLD2 sensitivity to chemotherapy drugs and its mechanism on tumor development are unknown. Methods: DCBLD2 expression differences in cancer and normal tissues were obtained from GEO and TCGA databases. DCBLD2 influence on prognosis was also compared, and the database analysis results were verified via the analysis of clin...
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#1Xiao-Yuan MaoH-Index: 19
#2Xi-Xi Yin (CSU: Central South University)H-Index: 1
Last. Weilin Jin (Lanzhou University)H-Index: 29
view all 8 authors...
Adequate food intake and relative abundance of dietary nutrients have undisputed effects on the brain function. There is now substantial evidence that dietary nutrition aids in the prevention and remediation of neurologic symptoms in diverse pathological conditions. The newly described influences of dietary factors on the alterations of mitochondrial dysfunction, epigenetic modification and neuroinflammation are important mechanisms that are responsible for the action of nutrients on the brain h...
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#1Yi-Xin Chen (CSU: Central South University)H-Index: 6
#2Li-Ming TanH-Index: 4
Last. Zhao-Qian Liu (CSU: Central South University)H-Index: 49
view all 8 authors...
PARP inhibitors are a group of inhibitors targeting poly(ADP-ribose) polymerases (PARP1 or PARP2) involved in DNA repair and transcriptional regulation, which may induce synthetic lethality in BRCAness tumors. Systematic analyzes of genomic sequencing in prostate cancer show that ~10%-19% of patients with primary prostate cancer have inactivated DNA repair genes, with a notably higher proportion of 23%-27% in patients with metastatic castration-resistant prostate cancer (mCRPC). These characteri...
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#1Chao Luo (CSU: Central South University)H-Index: 5
#2Xu Wang (CSU: Central South University)H-Index: 5
Last. Zhao-Qian Liu (CSU: Central South University)H-Index: 49
view all 6 authors...
OBJECTIVE Olanzapine is widely prescribed for patients with mental disorders; however, it may induce metabolic dysfunction. Metformin is an efficient adjuvant for preventing olanzapine-induced metabolic dysfunction in clinical practice. Although the mechanism of how metformin prevents this metabolic dysfunction remains unknown, changes in the gut-liver axis are considered a potential explanation. METHODS Forty-eight male rats were gavaged with olanzapine and/or metformin for 35 consecutive days....
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#1Shi-Long Jiang (CSU: Central South University)
#2Jun-Luan Mo (CSU: Central South University)H-Index: 2
Last. Wen-Xu HongH-Index: 2
view all 8 authors...
Deregulation of protein synthesis may be involved in multiple aspects of cancer, such as gene expression, signal transduction and drive specific cell biological responses, resulting in promoting cancer growth, invasion and metastasis. Study the molecular mechanisms about translational control may help us to find more effective anti-cancer drugs and develop novel therapeutic opportunities. Recently, the researchers had focused on targeting translational machinery to overcome cancer, and various s...
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#1Liyan WangH-Index: 2
#2Chang SunH-Index: 3
Last. Haijian WangH-Index: 14
view all 17 authors...
Objective: The expression and function of platinum transporters affect drug tissue concentration and therapeutic effects. We had previously characterized functional variant of platinum intake transporter SLC31A1 gene. We aimed to investigate the association of platinum efflux transporter gene ABCG2 polymorphism and combined ABCG2 and SLC31A1 polymorphisms with clinical outcomes of NSCLC patients receiving platinum-based chemotherapy. Methods: We genotyped thirteen tagging and functional SNPs of ...
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#1Tao Zhu (CSU: Central South University)H-Index: 13
#2Juyan Zheng (CSU: Central South University)H-Index: 1
Last. Zhao-Qian Liu (CSU: Central South University)H-Index: 49
view all 7 authors...
Breast cancer is one of the most lethal malignancies among women, and understanding the effects of host immunity on disease progression offers the potential to improve immunotherapies against it. Here, we constructed an immunity-related gene (IRG)-based prognostic signature to stratify breast cancer patients and predict their survival. We identified differentially-expressed genes by analyzing the breast cancer transcriptome data from The Cancer Genome Atlas. Univariate Cox regression revealed 17...
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