Original paper

βOHB Protective Pathways in Aralar-KO Neurons and Brain: An Alternative to Ketogenic Diet

Volume: 40, Issue: 48, Pages: 9293 - 9305
Published: Oct 21, 2020
Abstract
Aralar/AGC1/Slc25a12, the mitochondrial aspartate-glutamate carrier expressed in neurons, is the regulatory component of the NADH malate-aspartate shuttle. AGC1 deficiency is a neuropediatric rare disease characterized by hypomyelination, hypotonia, developmental arrest, and epilepsy. We have investigated whether β-hydroxybutyrate (βOHB), the main ketone body (KB) produced in ketogenic diet (KD), is neuroprotective in aralar -knock-out (KO)...
Paper Details
Title
βOHB Protective Pathways in Aralar-KO Neurons and Brain: An Alternative to Ketogenic Diet
Published Date
Oct 21, 2020
Volume
40
Issue
48
Pages
9293 - 9305
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