The Journal of Neuroscience
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Previous studies have shown that infiltration of capsaicin into the surgical site can prevent incision-induced spontaneous pain like behaviors and heat hyperalgesia. In the present study, we aimed to monitor primary sensory neuron Ca2+ activity in the intact dorsal root ganglia (DRG) using Pirt-GCaMP3 male and female mice pretreated with capsaicin or vehicle prior to the plantar incision. Intraplantar injection of capsaicin (0.05%) significantly attenuated spontaneous pain, mechanical, and heat ...
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#2Nakayla Chan (UA: University of Arizona)
Last. Shaowen BaoH-Index: 29
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Exposure to loud noises not only leads to trauma and loss of output from the ear, but also alters downstream central auditory circuits. A perceptual consequence of noise-induced central auditory disruption is impairment in gap-induced prepulse inhibition, also known as gap detection. Recent studies have implicated cortical parvalbumin-positive (PV) inhibitory interneurons in gap detection and prepulse inhibition. Here we show that exposure to loud noises specifically reduces the density of corti...
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#1Jorge Baruch Pineda-Farias (University of Pittsburgh)H-Index: 13
#2Emanuel Loeza-Alcocer (University of Pittsburgh)H-Index: 5
Last. Raymond F. Sekula (University of Pittsburgh)H-Index: 19
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Different peripheral nerve injuries cause neuropathic pain through distinct mechanisms. Even the site of injury may impact underlying mechanisms as indicated by the clinical finding that the anti-seizure drug carbamazepine (CBZ) relieves pain due to compression injuries of trigeminal but not somatic nerves. We leveraged this observation in the present study hypothesizing that because CBZ blocks voltage-gated sodium channels (VGSCs), its therapeutic selectivity reflects differences between trigem...
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#1Bastián Rivera (Usach: University of Santiago, Chile)H-Index: 1
#2Claudio Moreno (Usach: University of Santiago, Chile)
Last. María Pertusa (Usach: University of Santiago, Chile)H-Index: 13
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In mammals, environmental cold sensing carried out by peripheral cold thermoreceptor neurons mostly depends on TRPM8, an ion channel that has evolved to become the main molecular cold transducer. This TRP channel is activated by cold, cooling compounds such as menthol, voltage, and rises in osmolality. TRPM8 function is regulated by kinase activity that phosphorylates the channel under resting conditions. However, which specific residues, how this post-translational modification modulates TRPM8 ...
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#1Melanie Falgairolle (NIH: National Institutes of Health)H-Index: 5
#2Michael J. O'Donovan (NIH: National Institutes of Health)H-Index: 57
In the spinal cord, classes of interneurons have been studied in vitro to determine their role in producing or regulating locomotion. It is unclear whether all locomotor behaviors are produced by the same circuitry or engage different subsets of neurons. Here, in neonatal mice of either sex, we test this idea by comparing the actions of a class of spinal, inhibitory interneuron (V1) expressing channelrhodopsin driven by the engrailed-1 transcription factor on the rhythms elicited by different me...
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#1Elizabeth S. Maywood (LMB: Laboratory of Molecular Biology)H-Index: 45
#2Johanna E. CheshamH-Index: 24
Last. Michael H. HastingsH-Index: 87
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The timing and quality of sleep-wake cycles are regulated by interacting circadian and homeostatic mechanisms. Although the suprachiasmatic nucleus (SCN) is the principal clock, circadian clocks are active across the brain and the respective sleep-regulatory roles of SCN and local clocks are unclear. To determine the specific contribution(s) of the SCN, we used virally mediated genetic complementation, expressing Cryptochrome1 (Cry1) to establish circadian molecular competence in the suprachiasm...
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#1Meilin Wu (UCSD: University of California, San Diego)H-Index: 7
#2Clifford Z. Liu (UCSD: University of California, San Diego)H-Index: 1
Last. William J. Joiner (UCSD: University of California, San Diego)H-Index: 25
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α7 nAChRs are widely expressed in the brain where they promote fast cholinergic synaptic transmission and serve important neuromodulatory functions. However, their high permeability to Ca2+ also predisposes them to contribute to disease states. Here, using transfected HEK-tsa cells and primary cultured hippocampal neurons from male and female rats, we demonstrate that two proteins called Ly6h and NACHO compete for access to α7 subunits, operating together but in opposition to maintain α7 assembl...
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#1Anup DasH-Index: 7
#2Vinod Menon (Stanford University)H-Index: 110
Hippocampus and prefrontal cortex (PFC) circuits are thought to play a prominent role in human episodic memory, but the precise nature, and electrophysiological basis, of directed information flow between these regions and their role in verbal memory formation has remained elusive. Here we investigate nonlinear causal interactions between hippocampus and lateral PFC using intracranial EEG recordings (from both sexes) during verbal memory encoding and recall tasks. Direction-specific information ...
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#1Chuan Hou (Smith-Kettlewell Institute)H-Index: 11
#2Terence L. Tyson (Smith-Kettlewell Institute)H-Index: 2
Last. Preeti Verghese (Smith-Kettlewell Institute)H-Index: 22
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Binocular summation in strabismic amblyopia is typically reported as being absent or greatly reduced in behavioral studies and is thought to be due to a preferential loss of excitatory interactions between the eyes. Here, we studied how excitatory and suppressive interactions contribute to binocular contrast interactions along the visual cortical hierarchy of humans with strabismic and anisometropic amblyopia in both sexes, using source-imaged Steady-State Visual Evoked Potentials (SSVEP) over a...
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#1Sofía Polcowñuk (Fundación Instituto Leloir)
#2Taishi Yoshii (Okayama University)H-Index: 27
Last. M. Fernanda Ceriani (Fundación Instituto Leloir)H-Index: 12
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Rhythmic rest-activity cycles are controlled by an endogenous clock. In Drosophila, this clock resides in ∼150 neurons organized in clusters whose hierarchy changes in response to environmental conditions. The concerted activity of the circadian network is necessary for the adaptive responses to synchronizing environmental stimuli. Thus far work was devoted to unravel the logic of the coordination of different clusters focusing on neurotransmitters and neuropeptides. We further explored communic...
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