The Journal of Neuroscience
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#1Sukhbinder Kumar (Newcastle University)H-Index: 26
#2Pradeep Dheerendra (Newcastle University)H-Index: 3
Last. Timothy D. Griffiths (Newcastle University)H-Index: 63
view all 9 authors...
Misophonia is a common disorder characterized by the experience of strong negative emotions of anger and anxiety in response to certain everyday sounds, such as those generated by other people eating, drinking and breathing. The commonplace nature of these 'trigger' sounds makes misophonia a devastating disorder for sufferers and their families. How such innocuous sounds trigger this response is unknown. Since most trigger sounds are generated by orofacial movements (e.g. chewing) in others, we ...
#1Zhanmin Lin (EUR: Erasmus University Rotterdam)H-Index: 8
#2Bin Wu (EUR: Erasmus University Rotterdam)H-Index: 3
Last. Chris I. De Zeeuw (EUR: Erasmus University Rotterdam)H-Index: 72
view all 17 authors...
Protein phosphatase 2B (PP2B) is critical for synaptic plasticity and learning, but the molecular mechanisms involved remain unclear. Here we identified different types of proteins that interact with PP2B, among which structural proteins of the postsynaptic densities (PSDs) of Purkinje cells (PCs) in mice of either se. Deleting PP2B reduced expression of PSD proteins and the relative thickness of PSD at parallel fiber to PC synapses, whereas re-expression of inactive PP2B partly restored the imp...
#1Sangil Lee (UPenn: University of Pennsylvania)H-Index: 6
#2Trishala Parthasarathi (UPenn: University of Pennsylvania)H-Index: 3
Last. Joseph W. Kable (UPenn: University of Pennsylvania)H-Index: 32
view all 3 authors...
Recent work has shown that the brain's default mode network (DMN) is active when people imagine the future. Here we test in human participants (both sexes) whether future imagination can be decomposed into two dissociable psychological processes linked to different subcomponents of the DMN. While measuring brain activity with fMRI as subjects imagine future events, we manipulate the vividness of these events to modulate the demands for event construction, and we manipulate the valence of these e...
#1Li Wang (Fudan University)H-Index: 1
#2Wenwen Ren (Fudan University)H-Index: 2
Last. Yiqun Yu (Fudan University)H-Index: 6
view all 12 authors...
The adult olfactory epithelium (OE) regenerates sensory neurons and non-sensory supporting cells from resident stem cells after injury. How supporting cells contribute to OE regeneration remains largely unknown. In this study, we elucidated a novel role of Ym2 (also known as Chil4 or Chi3l4), a chitinase-like protein expressed in supporting cells, in regulating regeneration of the injured OE in vivo in both male and female mice and cell proliferation/differentiation in OE colonies in vitro We fo...
#1John C. Middlebrooks (UCI: University of California, Irvine)H-Index: 44
This is the story of a search for a cortical map of auditory space. The search began with a study that was reported in the first issue of the Journal of Neuroscience (Middlebrooks and Pettigrew, 1981, 1:107-120.). That paper described some unexpected features of spatial sensitivity in the auditory cortex while failing to demonstrate the expected map. In the ensuing 40 years, we have encountered: panoramic spatial coding by single neurons; a rich variety of response patterns that are unmasked in ...
#1Yi Liu (McGovern Institute for Brain Research)
#2Gaofeng Shi (BLCU: Beijing Language and Culture University)
Last. Zaizhu Han (McGovern Institute for Brain Research)H-Index: 19
view all 8 authors...
Visual word recognition, at a minimum, involves the processing of word form and lexical information. Opinions diverge on the spatiotemporal distribution of and interaction between the two types of information. Feedforward theory argues that they are processed sequentially, while interactive theory advocates that lexical information is processed fast and modulates early word form processing. To distinguish the two theories, we applied stereoelectroencephalography (SEEG) to 33 human adults with ep...
#1Benjamin de Haas (University of Giessen)H-Index: 12
#2Martin I. Sereno (UCL: University College London)H-Index: 50
Last. D. Samuel Schwarzkopf (UCL: University College London)H-Index: 12
view all 3 authors...
The ventral visual stream of the human brain is subdivided into patches with categorical stimulus preferences, like faces or scenes. However, the functional organization within these areas is less clear. Here, we used functional magnetic resonance imaging and vertex-wise tuning models to independently probe spatial and face-part preferences in the inferior occipital gyrus (IOG) of healthy adult males and females. The majority of responses were well explained by Gaussian population tuning curves ...
#1Tomoyuki Namima (UW: University of Washington)H-Index: 2
#2Anitha Pasupathy (UW: University of Washington)H-Index: 18
Object segmentation-the process of parsing visual scenes-is essential for object recognition and scene understanding. We investigated how responses of neurons in macaque inferior temporal (IT) cortex contribute to object segmentation under partial occlusion. Specifically, we asked whether IT responses to occluding and occluded objects are bound together as in the visual image, or linearly separable reflecting their segmentation. We recorded the activity of 121 IT neurons while animals performed ...
#1Liqiang Chen (Van Andel Institute)
#2Samuel Daniels (Van Andel Institute)
Last. Hong Yuan Chu (Van Andel Institute)H-Index: 10
view all 4 authors...
The hypokinetic motor symptoms of Parkinson's disease (PD) are closely linked with a decreased motor cortical output as a consequence of elevated basal ganglia inhibition. However, whether and how the loss of dopamine alters the cellular properties of motor cortical neurons in PD remains undefined. We induced parkinsonism in adult C57BL6 mice of both sexes by injecting neurotoxin, 6-hydroxydopamine, into the medial forebrain bundle. By using ex vivo patch-clamp recording and retrograde tracing a...
#1D. Leonardo Garcia Ramirez (Drexel University)
#2Ngoc T. Ha (Drexel University)H-Index: 5
Last. Kimberly J. Dougherty (Drexel University)H-Index: 17
view all 5 authors...
Neural circuitry generating locomotor rhythm and pattern is located in the spinal cord. Most spinal cord injuries (SCI) occur above the level of spinal locomotor neurons; therefore, these circuits are a target for improving motor function after SCI. Despite being relatively intact below the injury, locomotor circuitry undergoes substantial plasticity with the loss of descending control. Information regarding cell-type specific plasticity within locomotor circuits is limited. Shox2 interneurons (...
Top fields of study
Stimulus (physiology)
Cell biology