Original paper
Nucleic acid biohybrid nanocarriers with high‐therapeutic payload and controllable extended release of daunomycin for cancer therapy
Volume: 109, Issue: 7, Pages: 1256 - 1265
Published: Oct 26, 2020
Abstract
We have developed a novel, nanosized drug carrier with high-therapeutic payload, controllable release, and the potential for active tumor targeting. It consists of a 15 nm gold nanoparticle with dense surface loading of DNA duplexes. We utilize the natural intercalating behavior of daunomycin to load the drug between DNA base pairs. We obtained a high-therapeutic payload of >1,000 drug molecules per gold nanoparticle (AuNP), one of the highest...
Paper Details
Title
Nucleic acid biohybrid nanocarriers with high‐therapeutic payload and controllable extended release of daunomycin for cancer therapy
Published Date
Oct 26, 2020
Volume
109
Issue
7
Pages
1256 - 1265
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Notes
History