Journal of Biomedical Materials Research Part A
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#1AndreaGomez Sanchez (CONICET: National Scientific and Technical Research Council)
#2Maria Rosa Katunar (CONICET: National Scientific and Technical Research Council)H-Index: 4
Last. Silvia Ceré (CONICET: National Scientific and Technical Research Council)H-Index: 23
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The entire route from anodic oxidation and surface characterization, including in vitro experiments and finally in vivo osseointegration assays were performed with the aim to evaluate nanotubular and crystalline annealed titanium oxides as a suitable surface for grade 2 titanium permanent implants. Polished titanium (T0) was compared with anodized surfaces obtained in acidic media with fluoride, leading to an ordered nanotubular structure of titanium oxide on the metal surface, characterized by ...
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#1Tara B. Wigmosta (CSU: Colorado State University)H-Index: 2
#2Ketul C. Popat (CSU: Colorado State University)H-Index: 39
Last. Matt J. Kipper (CSU: Colorado State University)H-Index: 27
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Incomplete osseointegration is primary cause of failure for orthopedic implants. New biomaterials that present stable signals promoting osteogenesis could reduce failure rates of orthopedic implants. In this study bone morphogenetic protein-2 (BMP-2) was delivered from titania nanotubes (Nt) modified with chitosan/heparin polyelectrolyte multilayers (PEMs). The surfaces were characterized by scanning electron microscopy and X-ray photoelectron spectroscopy. BMP-2 release from the surfaces was me...
1 CitationsSource
#1Justin C. Burrell (UPenn: University of Pennsylvania)H-Index: 13
#2Divya Bhatnagar (RU: Rutgers University)H-Index: 13
Last. D. Kacy Cullen (UPenn: University of Pennsylvania)H-Index: 28
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Promising biomaterials should be tested in appropriate large animal models that recapitulate human inflammatory and regenerative responses. Previous studies have shown tyrosine-derived polycarbonates (TyrPC) are versatile biomaterials with a wide range of applications across multiple disciplines. The library of TyrPC has been well studied and consists of thousands of polymer compositions with tunable mechanical characteristics and degradation and resorption rates that are useful for nerve guidan...
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#1Ricky J. Whitener (Rowan University)H-Index: 1
#2Robert J. Mosley (Rowan University)
Last. Mark E. Byrne (Rowan University)H-Index: 2
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We have developed a novel, nanosized drug carrier with high-therapeutic payload, controllable release, and the potential for active tumor targeting. It consists of a 15 nm gold nanoparticle with dense surface loading of DNA duplexes. We utilize the natural intercalating behavior of daunomycin to load the drug between DNA base pairs. We obtained a high-therapeutic payload of >1,000 drug molecules per gold nanoparticle (AuNP), one of the highest loadings reported in literature to date. We have eng...
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#1Maytha Sareethammanuwat (Thammasat University)H-Index: 1
#2Supakorn Boonyuen (Thammasat University)H-Index: 5
Last. Premjit Arpornmaeklong (Thammasat University)H-Index: 5
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In the present study, an inorganic matrix of beta-tricalcium phosphate (bTCP) nanoparticles and quercetin was incorporated into an organic matrix of 2:1 (w/w) chitosan/collagen composite to fabricate thermosensitive bTCP-chitosan/collagen-quercetin hydrogels. A sol-gel transition of the hydrogels was stimulated by beta-glycerophosphate (bGP) and temperature changes at physiological temperature and pH levels. Thereafter, the effects of 1%-3% (w/v) bTCP on properties of the bTCP-bGP-2:1 (w/w) chit...
1 CitationsSource
#1Sayema Raiyan (University of Chittagong)
#2Atiar Rahman (University of Chittagong)H-Index: 8
Last. Bijo MathewH-Index: 25
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The current study investigated the immunomodulating and osteoblast differentiation potential of the natural compounds from Leea macrophylla (LMN). Immunomodulatory effects have been investigated by the phagocytosis of Candida albicans using polymorphonuclear neutrophil cells in the in vitro slide method. A bioactivity-guided fractionation technique was used to evaluate the stimulating effect of L. macrophylla methanol extract on osteoblast differentiation using mouse osteoblastic cells. A low do...
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#1Ryan Borem (Clemson University)H-Index: 3
#2Joshua Walters (Clemson University)H-Index: 4
Last. Jeremy Mercuri (Clemson University)H-Index: 10
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Intervertebral disc (IVD) degeneration (IVDD) leads to structural and functional changes. Biomaterials for restoring IVD function and promoting regeneration are currently being investigated; however, such approaches require validation using animal models that recapitulate clinical, biochemical, and biomechanical hallmarks of the human pathology. Herein, we comprehensively characterized a sheep model of chondroitinase-ABC (ChABC) induced IVDD. Briefly, ChABC (1 U) was injected into the L1/2 , L2/...
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#1Renata Moraes Lira (Federal Fluminense University)
#2Suelen Cristina Sartoretto (Federal Fluminense University)H-Index: 10
Last. José Mauro Granjeiro (Federal Fluminense University)H-Index: 54
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In daily clinical practice, there is a notable variety of synthetic bone substitute, with various resorption rates, different chemical and structural characteristics that influence on bone regeneration and are not suitable for every clinical use. New biomaterials based on nanotechnology have been developed to be bioabsorbable as new bone is formed. This study intends to evaluate THP-1 cell viability when exposed to extracts of unsintered nanostructured carbonated hydroxyapatite (cHA) microsphere...
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#1Han Li (CQMU: Chongqing Medical University)H-Index: 1
#2Jie Zhou (CQMU: Chongqing Medical University)
Last. Jinlin Song (CQMU: Chongqing Medical University)H-Index: 15
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Human periodontal ligament stem cells (hPDLSCs) sheets play an important role in periodontal tissue engineering. Low-intensity pulsed ultrasound (LIPUS) has been reported as an effective stimulus to regulate cell biological behavior. The present study aims to explore the potential of LIPUS to promote the formation and function of hPDLSC sheets (hPDLSCSs). Hematoxylin-eosin (H&E) staining, western blot, real-time PCR, alkaline phosphatase (ALP), and alizarin red staining were used to evaluate the...
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#1Guillermo Grazioli (University of the Republic)H-Index: 5
Last. Rafael R. MoraesH-Index: 33
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Novel poly(vinyl alcohol)/chondroitin sulfate (PVA/CS) composite hydrogels containing hydroxyapatite (HA) or Sr-doped HA (HASr) particles were synthesized by a freeze/thaw method and characterized aiming towards biomedical applications. HA and HASr were synthesized by a wet-precipitation method and added to the composite hydrogels in fractions up to 15 wt%. Physical-chemical characterizations of particles and hydrogels included scanning electron microscopy, energy-dispersive spectroscopy, Fourie...
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