Genetic Variants in the Regulatory T cell–Related Pathway and Colorectal Cancer Prognosis

High numbers of lymphocytes in tumor tissue, including T regulatory cells (Treg), have been associated with better colorectal cancer survival. Tregs, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and therefore variants in genes related to Treg differentiation and function could be associated with colorectal cancer prognosis.In a prospective German cohort of 3,593 colorectal cancer patients, we assessed the...