Cancer Epidemiology, Biomarkers & Prevention
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Strategic planning is conducted by many organizations to systematically evaluate and assess their current state, establish or update their mission and/or goals, and identify strategies and activities to achieve the goals. The National Cancer Institute (NCI) Cohort Consortium is a collaborative network of 62 prospective cohort studies and their affiliated investigators that focus on cancer etiology and outcome research. The organization's membership grew markedly from 10 cohort studies at its inc...
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#1Wei Yi Kong (UNC: University of North Carolina at Chapel Hill)
#2Gabriela Bustamante (UMN: University of Minnesota)H-Index: 3
Last. Melissa B. Gilkey (UNC: University of North Carolina at Chapel Hill)H-Index: 27
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Infrequent provider recommendations continue to be a key barrier to human papillomavirus (HPV) vaccination, including among adolescents at higher risk for future HPV cancers. To inform future interventions, we sought to characterize disparities in healthcare providers' HPV vaccine recommendation for US adolescents. We systematically reviewed studies published in 2012-2019 that assessed provider HPV vaccine recommendations for adolescents aged 9-17. Following PRISMA guidelines, we identified 52 e...
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Background: Tumor necrosis factor inhibitors (TNFis) effectively treat rheumatoid arthritis (RA) but may increase patient risk of some malignancies, particularly lymphomas or skin cancers. Methods: We used Surveillance, Epidemiology, and End Results (SEER)-Medicare data to conduct a case-control study in RA patients (2007-2015). Cases were individuals with a first cancer diagnosed in SEER registries (ages 66-99, 22 cancer sites, N=10,263). Skin cancer cases (non-melanoma skin cancer overall [NMS...
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#1Florentin Späth (Umeå University)H-Index: 8
#2Wendy Yi Ying Wu (Umeå University)H-Index: 8
Last. Roel Vermeulen (UU: Utrecht University)H-Index: 83
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Background: Changes in immune marker levels in the blood could be used to improve the early detection of tumor-associated inflammatory processes. To increase predictiveness and utility in cancer detection, intra-individual long-term stability in cancer-free individuals is critical for biomarker candidates as to facilitate the detection of deviation from the norm. Methods: We assessed intra-individual long-term stability for 19 immune markers (IL-10, IL-13, TNF-α, CXCL13, MCP-3, MIP-1α, MIP-1β, f...
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#1Kimberly D. Miller (ACS: American Cancer Society)H-Index: 28
#2Rebecca L. Siegel (ACS: American Cancer Society)H-Index: 67
Last. Huann Sheng ChenH-Index: 19
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Background: The American Cancer Society (ACS) and the National Cancer Institute collaborate every 5-8 years to update the methods for estimating the numbers of new cancer cases and deaths in the current year for the U.S. and individual states. Herein, we compare our current projection methodology with the next generation of statistical models. Methods: null A validation study was conducted comparing current projection methods (vector autoregression for incidence; Joinpoint regression for mortali...
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Background: The association between circulating cholesterol and triglyceride levels and ovarian cancer risk remains unclear. Methods: We prospectively evaluated the association between cholesterol (total, low density lipoprotein (LDL-C), and high density lipoprotein (HDL-C)) and triglycerides and ovarian cancer incidence in a case-control study nested in the Nurses9 Health Study (NHS) and NHSII cohorts and a longitudinal analysis in the UK Biobank. Results: A total of 290 epithelial ovarian canc...
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Background: Improvements in cancer survival are usually assessed by comparing survival in grouped years of diagnosis. To enhance analyses of survival trends, we present the joinpoint survival model webtool (JPSurv ) that analyses survival data by single year of diagnosis and estimates changes in survival trends and year-over-year trend measures. null Methods: We apply JPSurv to relative survival data for individuals diagnosed with female breast cancer, melanoma cancer, Non-Hodgkin Lymphoma (NHL)...
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Background: Bile acid (BA) and short chain fatty acid (SCFA) production is impacted by diet and microbial metabolism. These metabolites may play important roles in human carcinogenesis. Methods: We used a fully quantitative targeted liquid chromatography-mass spectrometry (LC-MS/MS) system to measure serum and fecal BA and SCFA concentrations in 136 Costa Rican adults at study baseline and 6-months. We randomly selected 50 participants and measured their baseline samples in duplicate. Our object...
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#1Ronald C. Eldridge (Emory University)H-Index: 7
#2Karan Uppal (Emory University)H-Index: 28
Last. Kristin Higgins (Emory University)H-Index: 29
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Background: Metabolic differences between human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) and smoking-associated HNSCC may partially explain differences in prognosis. The former relies on mitochondrial oxidative phosphorylation (OXPHOS) while the latter relies on glycolysis. These differences have not been studied in blood. Methods: We extracted metabolites using untargeted liquid chromatography high-resolution mass spectrometry from pretreatment plasma in a c...
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#1J. Lee Westmaas (ACS: American Cancer Society)H-Index: 16
#2Sara Strollo (ACS: American Cancer Society)H-Index: 3
Last. Johannes Thrul (Johns Hopkins University)H-Index: 18
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Background: Cannabis use is increasing, including among smokers, an at-risk population for cancer. Research is equivocal on whether using cannabis inhibits quitting cigarettes. The current longitudinal study investigated associations between smoking cannabis and subsequently quitting cigarettes. Methods: Participants were 4,535 adult cigarette smokers from a cohort enrolled in the American Cancer Society9s Cancer Prevention Study-3 in 2009-2013. Cigarette quitting was assessed on a follow-up sur...
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