Jenny Chang-Claude
German Cancer Research Center
Genome-wide association studyEpidemiologyCancerInternal medicineGenotypeOncologyCase-control studySingle-nucleotide polymorphismOdds ratioGenetic associationOvarian cancerPopulationGynecologyConfidence intervalRisk factorColorectal cancerBreast cancerGeneticsMedicineBiology
Publications 911
#1Joe Dennis (University of Cambridge)H-Index: 55
#2Tyrer Jp (University of Cambridge)H-Index: 2
Last. Douglas F. Easton (University of Cambridge)H-Index: 172
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Background: Copy number variants (CNVs) are pervasive in the human genome but potential disease associations with rare CNVs have not been comprehensively assessed in large datasets. We analysed rare CNVs in genes and non-coding regions for 86,788 breast cancer cases and 76,122 controls of European ancestry with genome-wide array data. Results: Gene burden tests detected the strongest association for deletions in BRCA1 (P= 3.7E-18). Nine other genes were associated with a p-value < 0.01 including...
#1Joseph S Baxter (ICR: Institute of Cancer Research)H-Index: 1
#2Nichola Johnson (ICR: Institute of Cancer Research)H-Index: 46
Last. Qin Wang (University of Cambridge)H-Index: 43
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A combination of genetic and functional approaches has identified three independent breast cancer risk loci at 2q35. A recent fine-scale mapping analysis to refine these associations resulted in 1 (signal 1), 5 (signal 2), and 42 (signal 3) credible causal variants at these loci. We used publicly available in silico DNase I and ChIP-seq data with in vitro reporter gene and CRISPR assays to annotate signals 2 and 3. We identified putative regulatory elements that enhanced cell-type-specific trans...
1 CitationsSource
#1Sophie Scherer-Trame (Heidelberg University)
#2Lina Jansen (DKFZ: German Cancer Research Center)H-Index: 38
Last. Hermann Brenner (DKFZ: German Cancer Research Center)H-Index: 165
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BACKGROUND Inpatient rehabilitation therapy (IRT) is commonly offered to cancer patients during or after cancer treatment in Germany. However, little is known about utilization and long-term effects of this offer in colorectal cancer (CRC) patients. We aimed to assess IRT utilization, determinants of utilization and the association between IRT and survival in CRC patients. MATERIALS AND METHODS CRC patients diagnosed in 2005-2014 recruited in the population-based DACHS study in South West German...
#9Will T. Rosenow (UVA: University of Virginia)H-Index: 1
#10Fernando Salvador Moreno (Hospital Clínico San Carlos)H-Index: 28
#1Xiaoliang Wang (Fred Hutchinson Cancer Research Center)H-Index: 6
#2Efrat L. Amitay (DKFZ: German Cancer Research Center)H-Index: 5
Last. Andrew T. Chan (Harvard University)H-Index: 110
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#3Xiangwei Li (Heidelberg University)H-Index: 1
Leukocytes are involved in the progression of colorectal cancer (CRC). The proportion of six major leukocyte subtypes can be estimated using epigenome-wide DNA methylation (DNAm) data from stored blood samples. Whether the composition of circulating leukocytes can be used as a prognostic factor is unclear. DNAm-based leukocyte proportions were obtained from a prospective cohort of 2206 CRC patients. Multivariate Cox regression models and survival curves were applied to assess associations betwee...
#1Xuechen Chen (DKFZ: German Cancer Research Center)H-Index: 2
#2Feng Guo (Heidelberg University)H-Index: 3
Last. Hermann Brenner (DKFZ: German Cancer Research Center)H-Index: 165
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BACKGROUND The regular use of non-steroidal anti-inflammatory drugs (NSAIDs) has been associated with reduced colorectal cancer (CRC) risk. AIM To explore whether this association varies according to background polygenic risk for CRC. METHODS Data were collected from a large population-based case-control study on CRC in Germany. A polygenic risk score (PRS) based on 140 CRC-related risk loci was used to quantify the genetic risk. The associations of regular use of NSAIDs (≥2times per week for at...
#1Xiaoliang WangH-Index: 6
Last. Sara LindströmH-Index: 60
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#1Alexi N. Archambault (NYU: New York University)H-Index: 2
#2Yi Lin (Fred Hutchinson Cancer Research Center)H-Index: 21
Last. Richard B. Hayes (NYU: New York University)H-Index: 86
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Background Incidence of early-onset (younger than 50 years of age) colorectal cancer (CRC) is increasing in many countries. Thus, elucidating the role of traditional CRC risk factors in early-onset CRC is a high priority. We sought to determine whether risk factors associated with late-onset CRC were also linked to early-onset CRC and whether association patterns differed by anatomic subsite. Methods Using data pooled from 13 population-based studies, we studied 3767 CRC cases and 4049 controls ...
#1Juliette CoignardH-Index: 1
Last. Antonis C. Antoniou (University of Cambridge)H-Index: 83
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