CAR T cells targeting tumor endothelial marker CLEC14A inhibit tumor growth

Volume: 5, Issue: 19
Published: Oct 2, 2020
Abstract
Engineering T cells to express chimeric antigen receptors (CARs) specific for antigens on hematological cancers has yielded remarkable clinical responses, but with solid tumors, benefit has been more limited. This may reflect lack of suitable target antigens, immune evasion mechanisms in malignant cells, and/or lack of T cell infiltration into tumors. An alternative approach, to circumvent these problems, is targeting the tumor vasculature...
Paper Details
Title
CAR T cells targeting tumor endothelial marker CLEC14A inhibit tumor growth
Published Date
Oct 2, 2020
Journal
Volume
5
Issue
19
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