Last. Xia He(Nanjing Medical University)H-Index: 14
view all 6 authors...
Abstract Objectives This study aimed to validate the 8th edition of American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) TNM staging system for nasopharyngeal carcinoma (NPC) in non-endemic region. Materials and methods We recruited 607 patients with histology-proven, previously untreated, non-metastatic NPC treated by intensity-modulated radiotherapy (IMRT) at our center. Harrell’s concordance index (c-index) and Akaike information criterion (AIC) were applied t...
#1Anne W.M. Lee(HKU: University of Hong Kong)H-Index: 48
#1Anne W. Lee(HKU: University of Hong Kong)H-Index: 3
Last. Joseph Wee(NUS: National University of Singapore)H-Index: 35
view all 29 authors...
Abstract Purpose The treatment of nasopharyngeal carcinoma (NPC) requires high radiation doses. The balance of the risks of local recurrence due to inadequate tumor coverage versus the potential damage to the adjacent organs at risk (OARs) is of critical importance. With advancements in technology, high target conformality is possible. Nonetheless, to achieve the best possible dose distribution, optimal setting of dose targets and dose prioritization for tumor volumes and various OARs is fundame...
#1Chong Zhao(SYSU: Sun Yat-sen University)H-Index: 31
#2Jing Jing Miao(SYSU: Sun Yat-sen University)H-Index: 1
Last. Conghua Xie(WHU: Wuhan University)H-Index: 23
view all 13 authors...
Purpose To evaluate the long-term locoregional control, failure patterns, and late toxicity after reducing the target volume and radiation dose in patients with locoregionally advanced nasopharyngeal carcinoma patients treated with induction chemotherapy (IC) plus concurrent chemoradiotherapy (CCRT). Methods and Materials Previously untreated patients with locoregionally advanced nasopharyngeal carcinoma were recruited into this prospective study. All patients received 2 cycles of IC followed by...
Background: To develop and validate a radiomic nomogram incorporating radiomic features with clinical variables for individual local recurrence risk assessment in nasopharyngeal carcinoma (NPC) patients before initial treatment. Methods: One hundred and forty patients were randomly divided into a training cohort (n = 80) and a validation cohort (n = 60). A total of 970 radiomic features were extracted from pretreatment magnetic resonance (MR) images of NPC patients from May 2007 to December 2013...
Abstract Purpose To evaluate treatment outcomes, failure patterns and late toxicities in patients with nasopharyngeal carcinoma (NPC) treated by intensity modulated radiotherapy (IMRT) in 6 public hospitals in Hong Kong over a 10-year period from 2001 to 2010. Material and methods Eligible patients were identified through the Hong Kong Cancer Registry data base. Clinical information was retrieved and verified by oncologists working in the individual centers. Treatment details, survival outcomes ...
#1Lu-Lu Zhang(SYSU: Sun Yat-sen University)H-Index: 7
#2Yi Yang Li(Guangdong Pharmaceutical University)H-Index: 2
Last. Ying Sun(SYSU: Sun Yat-sen University)H-Index: 43
view all 10 authors...
PURPOSE: Local relapse-free survival (LRFS) differs widely among patients with T4 category nasopharyngeal carcinoma (NPC). We aimed to build a nomogram incorporating clinicopathological information to predict LRFS in T4 NPC after definitive intensity-modulated radiation therapy (IMRT). Materials and Methods: Retrospective study of 415 Chinese patients with non-metastatic T4 NPC treated with definitive IMRT with or without chemotherapy at our cancer center between October 2009 and September 2013....
Last. Jingbo Wu(CQMU: Chongqing Medical University)H-Index: 2
view all 26 authors...
Abstract Purpose To investigate whether reducing the target volume of intensity-modulated radiotherapy (IMRT) after induction chemotherapy (IC) improves the quality of life (QOL) in locoregionally advanced nasopharyngeal carcinoma (NPC) without decreasing the local control and survival rate. Patients and methods A total number of 212 NPC patients staged as III–IVb were randomly assigned to group A ( n = 97) or group B ( n = 115) in this prospective clinical trial. All patients received IC follow...
PURPOSE: A common problem in stage T3-4 nasopharyngeal carcinoma (NPC) is the narrow gap between the primary tumor and neurological structures, which makes dose optimization difficult. Considering that significant tumor shrinkage may occur during induction chemotherapy (IC), this study explored the efficacy of intensity-modulated radiotherapy (IMRT) using reduced gross tumor volume (GTV) in the treatment of T3-4 NPC. PATIENTS AND METHODS: Between January 2009 and April 2014, 103 patients with no...
Last. Ying Sun(SYSU: Sun Yat-sen University)H-Index: 43
view all 9 authors...
Background: The aim of this study was to build nomograms to predict local recurrence (LR) and regional recurrence (RR) in patients with nasopharyngeal carcinoma (NPC) underwent intensity-modulated radiation therapy (IMRT). Patients and Methods : A total of 1811 patients with non-metastatic NPC treated with IMRT (with or without chemotherapy) between October 2009 and February 2012 at our center were involved for building the nomograms. Nomograms for LR-free rate and RR-free rate at 3- and 5- year...