Internal medicine

Clinical endpoint

Prostate cancer

Salvage therapy

Prostate-specific antigen

Cancer

Urology

Surgery

Oncology

Randomized controlled trial

Chemotherapy

Prostatectomy

Androgen deprivation therapy

Radiation therapy

Medicine

The Lancet Oncology

Salvage radiotherapy did not meet trial specified criteria for non-inferiority. However, these data support the use of salvage radiotherapy as it results in similar biochemical control to adjuvant radiotherapy, spares around half of men from pelvic radiation, and is associated with significantly lower genitourinary toxicity.

Adjuvant radiotherapy versus early salvage radiotherapy following radical prostatectomy (TROG 08.03/ANZUP RAVES): a randomised, controlled, phase 3, non-inferiority trial