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Original paper

The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution

Volume: 11, Issue: 1
Published: Sep 21, 2020
Abstract
The immune system can recognize and attack cancer cells, especially those with a high load of mutation-induced neoantigens. Such neoantigens are abundant in DNA mismatch repair (MMR)-deficient, microsatellite-unstable (MSI) cancers. MMR deficiency leads to insertion/deletion (indel) mutations at coding microsatellites (cMS) and to neoantigen-inducing translational frameshifts. Here, we develop a tool to quantify frameshift mutations in MSI...
Paper Details
Title
The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution
Published Date
Sep 21, 2020
Volume
11
Issue
1
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