Original paper
The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution
Abstract
The immune system can recognize and attack cancer cells, especially those with a high load of mutation-induced neoantigens. Such neoantigens are abundant in DNA mismatch repair (MMR)-deficient, microsatellite-unstable (MSI) cancers. MMR deficiency leads to insertion/deletion (indel) mutations at coding microsatellites (cMS) and to neoantigen-inducing translational frameshifts. Here, we develop a tool to quantify frameshift mutations in MSI...
Paper Details
Title
The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution
Published Date
Sep 21, 2020
Journal
Volume
11
Issue
1