Abstract 3120: Genetic heterogeneity profiling forHER2positive single circulating tumor cell (CTC) in metastatic breast cancer (MBC) by application of DEPArrayTM System and single cell DNA sequencing forHER2positive single circulating tumor cell (CTC) in metastatic breast cancer (MBC) by applicationDEPArrayTMsystem and single cell DNA sequencing

Introduction: Although CTCs display the same spatial and temporal heterogeneity as the primary tumor, they represent a privileged window to disclose mechanisms of metastases. We previously reported that overexpression of HER2 in CTCs is associated with worse prognosis in MBC (2018 AACR #5195). Herein, we report a new finding of heterogeneity profiling for HER2 positive CTC by using a new approach for single CTC isolation and sequencing. Methods:...