Exploring role of probiotics and Ganoderma lucidum extract powder as solid carriers to solidify liquid self-nanoemulsifying delivery systems loaded with curcumin.
Abstract Solid self-nanoemulsifying drug delivery system (S-SENDDS) containing Curcumin (CRM) were prepared using combination of Ganoderma lucidium extract powder (GLEP) and probiotics (PB) as carriers. Liquid SNEDDS containing CRM were prepared by mixing Capmul MCM, Labrafil M1944CS, Tween 80 and Transcutol P. These were further spray dried and finally converted into spheroids. The droplet size of reconstituted S-SNEDDS powder and spheroids was found in the range of 35 to 37 nm, zeta potential in the range of - 21.48 to -23.22 mV and drug loading in the range of 95-96%. The release of drug from formulations was found to be more than 90%. Similarly, significant improvement (p 0.05) in drug loading, droplet size, dissolution rate and angle of repose between L-SNEDDS and S-SNEDDS indicated the potential of GLEP-PB to produce stable SNEDDS.
Last. Ankit Awasthi(LPU: Lovely Professional University)H-Index: 7
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Abstract Diabetes mellitus is a metabolic disorder due to increased level of glucose in blood that affects millions of individuals. If not managed properly, it can lead to life threatening complications, organ failure and mortality. Research has recognized that diabetes can be prevented and managed by following proper lifestyle which includes diet and exercise. Though a number of synthetic drugs are available for managing this condition, their long-term use is associated with many side effects. ...
Last. Shibanand Sinha(LPU: Lovely Professional University)H-Index: 1
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AbstractDevelopment of self-nanoemulsifying drug delivery systems (SNEDDS) of docosahexaenoic acid (DHA) is reported with the aim to achieve enhanced dissolution rate. The optimized composition of ...
Abstract The study entailed formulation of gold nanoparticles (AuNPs) upon reduction of chloroauric acid by modified apple polysaccharide (MAP). AuNPs were conjugated with insulin (INS) for its oral delivery to treat type 1 diabetes mellitus (DM). The size of MAP conjugated AuNPs loaded with INS was 124 ± 8.55 nm with zeta potential −10.5 ± 0.54 mV. The animal study carried out in streptozotocin induced rat model revealed that AuNPs conjugated insulin (AuNPs-INS) in high dose caused 3.36 folds d...
#3Rakesh Kumar(LPU: Lovely Professional University)
Abstract Fisetin is a plant derived flavonoid that possesses anti-cancer, anti-oxidant and anti-Parkinson's activities. However, due to its lipophilicity it suffers from dissolution rate limited oral bioavailability that reduces its therapeutic efficacy. In order to overcome this issue self-nanoemulsifying drug delivery system (SNEDDS) of fisetin were formulated and characterized for droplet size, shape, zeta potential, cell viability, dissolution and permeability studies. Prepared SNEDDS (1.2 m...
Last. Kamal Dua(UTS: University of Technology, Sydney)H-Index: 28
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Abstract The growing disease burden of diabetes mellitus is an important public health concern, affecting over 400 million people globally. This epidemic, if not controlled in time, leads to life threatening complications, compromise in quality of life, and eventually mortality. Over time, many attempts have been made for the effective treatment of diabetes but true success has never been achieved. Pharmacological and non-pharmacological approaches for the treatment of hyperglycaemia have been e...
Last. Rakesh Narang(Kurukshetra University)H-Index: 15
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The aim of present study was to co-administer curcumin (CRM) liquisolid pellets and coated duloxetine hydrochloride (DXH) pellets in rats to treat neuropathic pain (NP) associated with chronic constriction injury (CCI). To formulate liquisolid pellets of CRM, it was first dissolved in Tween-80 and then adsorbed on the porous surface of MCC PH102 and Syloid XDP that were used as carrier and coating materials, respectively. Central composite design was used to optimize the liquisolid formulation. ...
#1Varun Garg(LPU: Lovely Professional University)H-Index: 7
#2Puneet Kaur(WSU: Washington State University)H-Index: 1
Last. Sheetu Wadhwa(LPU: Lovely Professional University)H-Index: 13
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Abstract An attempt has been made to prepare solid self-nanoemulsifying drug delivery system (SNEDDS) of polypeptide-k (PPK) and curcumin (CRM) using Labrafil M1944 CS as oil, Tween-80 as surfactan...
Objective: The aim of this study was to investigate the in vitro and in vivo performance of self-nanoemulsifying drug delivery systems (SNEDDS) of talinolol (TAL), a poorly water soluble drug. Method: SNEDDS of TAL were prepared using various oils, non-ionic surfactants and/or water-soluble co-solvents and assessed visually/by droplet size measurement. Equilibrium solubility of TAL in the anhydrous and diluted SNEDDS was conducted to achieve the maximum drug loading. The in vitro dissolution exp...
Last. Rubiya Khursheed(LPU: Lovely Professional University)H-Index: 9
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Abstract In the present study, different solid self-nanoemulsifying drug delivery system (S-SNEDDS) was formulated by using porous hydrophilic and hydrophobic carriers to improve the dissolution rate and bioavailability of simvastatin (SIM). The prepared liquid-SNEDDS composed of Labrafil M 1944 CS/ Tween-80/ Ethanol (20% / 53.33%/26.67% v/v) with 0.1% SIM, resulted droplet size of 40.69 nm. The hydrophobic carriers used were Aerosil-200, Syloid 244FP, Syloid XDP 3150, Magnesium stearate, Micro ...
#1Bimlesh Kumar(LPU: Lovely Professional University)H-Index: 12
#2Varun Garg(LPU: Lovely Professional University)H-Index: 7
Last. Sachin Kumar Singh(LPU: Lovely Professional University)H-Index: 19
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Abstract Advantage of spray drying technique over the conventional surface adsorption technique for co-formulation of solid SNEDDS (S-SNEDDS) of curcumin (CRM) and duloxetine (DXH) is discussed. Liquid SNEDDS were prepared using castor oil (20% w/w), Tween-80 (40% w/w) and Transcutol® P (40% w/w) as oil, surfactant and co-surfactants containing both CRM and DXH. S-SNEDDS were formulated by adsorption of liquid SNEDDS onto porous hydrophilic and hydrophobic carriers through spray drying and surfa...
Control of hyperglycemia and prevention of glucose reabsorption (glucotoxicity) are important objectives in the management of type 2 diabetes. This study deals with an oral combined dosage form design for two anti-diabetic drugs, sitagliptin and dapagliflozin using self-nanoemulsifying drug delivery systems (SNEDDS). The SNEDDS were developed using naturally obtained bioactive medium-chain/long-chain triglycerides oil, mixed glycerides and nonionic surfactants, and droplet size was measured foll...
Last. Kyung Taek Oh(CAU: Chung-Ang University)H-Index: 31
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Abstract null null The purpose of this study was to use hydroxypropyl-β-cyclodextrin (HP-β-CD) as a novel carrier in solid SNEDDS and solid dispersions to enhance the solubility and oral bioavailability of poorly water-soluble dexibuprofen. The novel dexibuprofen-loaded solid SNEDDS was composed of dexibuprofen, corn oil, polysorbate 80, Cremophor® EL, and HP-β-CD at a weight ratio of 45/35/50/15/100. This solid SNEDDS spontaneously formed a nano-emulsion with a size of approximately 120 nm. Unl...
The role of mushroom polysaccharides and probiotics as pharmaceutical excipients for development of nanocarriers has never been explored. In the present study an attempt has been made to explore Ganoderma lucidum extract powder (GLEP) containing polysaccharides and probiotics to convert liquid self nanoemulsifying drug delivery system (SNEDDS) into solid free flowing powder. Two lipophilic drugs, curcumin and quercetin were used in this study due to their dissolution rate limited oral bioavailab...
Last. Raisuddin Ali(KSU: King Saud University)H-Index: 10
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Abstract In the current study, a novel self-nanoemulsifying drug delivery system (SNEDDS) was developed in order to improve the oral bioavailability of delafloxacin (DLF). Various oils, surfactants and co-surfactants were screened by solubility studies. Based on solubilization, potential of DLF in various vehicles, LauroglycolTM-90 (oil), Tween® 80 (surfactant) and Transcutol®-HP (co-surfactant) were selected for the development of DLF loaded SNEDDS (DLF-SNEDDS). Four formulae of DLF loaded SNED...
Abstract null null This work aimed to develop, optimize, and evaluate the hypoglycemic activity of P. ligularis leaves extract (PLE) loaded self-emulsifying drug delivery system (SEDDS). The formulation components (oil, surfactant, and co-solvent) were selected based on the solubility studies. A Box-Behnken design (BBD) with 27 treatments was employed to find the optimal composition of PLE-SEDDS, analyzing the droplet size as the response variable. The polydispersity index (PDI) and zeta potenti...
Last. Hani Z. Asfour(KAU: King Abdulaziz University)H-Index: 14
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Abstract Pancreatic cancers are mostly inoperable and have a low survival rate. Nanomedicine has provided some promise in overcoming some major hurdles in pancreatic cancer. Meanwhile, resveratrol (RESV) has been reported to be useful in pancreatic cancer therapeutics. Therefore, the purpose of the study was to develop SNEDDS formulation of RESV for therapeutic application in pancreatic cancer therapy. Capryol 90, Cremophor RH, and Transcutol P were selected as the oil, surfactant, and co-surfac...
Last. Rafa Almeer(KSU: King Saud University)H-Index: 15
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Huntington disease (HD) is a type of neurodegenerative disease that is characterized by presence of multiple repeats (more than 36) of cytosine-adenine-guanine (CAG) trinucleotides and mutated huntingtin (mHtt). This can further lead to oxidative stress, enhancement in level of ROS/RNS, mitochondrial dysfunction and neuroinflammations. Many clinical and preclinical trials have been conducted so far for the effective treatment of HD however, none of the drugs has shown complete relief. The regene...
#1Yi-Meng Li(SCUT: South China University of Technology)H-Index: 1
#2Rui-fang Zhong(SCUT: South China University of Technology)
Last. Zhigang Luo(SCUT: South China University of Technology)H-Index: 23
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Russula virescens is an edible wild mushroom that is widely distributed in south of China. This research aimed to analyze the structure characterization and evaluate the hypoglycemic, anticancer and immunological activities of two water soluble polysaccharides RVP-1 and RVP-2 from R. virescens. The results showed RVP-1 and RVP-2 were non-triple helix structured hetero-polysaccharides with different weight-average molecular weight 14,883 and 13,301 Da, respectively. Both RVP-1 and RVP-2 were comp...
Last. Sumana Mondal(LPU: Lovely Professional University)
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Abstract Ganoderma lucidium extract powder (GLEP) contains various polysaccharides which are well known for their antioxidant and anti-inflammatory actions. Probiotics (PB) are well-established for providing a plethora of health benefits. Hence, use of mushroom polysaccharides and probiotics as carriers to solidify liquisolid formulation is anticipated to function as functional excipients i.e. as adsorbent that may provide therapeutic benefits. Quercetin (QUR) has been used as model lipophilic d...
