Exploring role of probiotics and Ganoderma lucidum extract powder as solid carriers to solidify liquid self-nanoemulsifying delivery systems loaded with curcumin.

Published on Dec 15, 2020in Carbohydrate Polymers7.182
· DOI :10.1016/J.CARBPOL.2020.116996
Rubiya Khursheed9
Estimated H-index: 9
(LPU: Lovely Professional University),
Sachin Kumar Singh19
Estimated H-index: 19
(LPU: Lovely Professional University)
+ 7 AuthorsLeander Corrie5
Estimated H-index: 5
(LPU: Lovely Professional University)
Abstract Solid self-nanoemulsifying drug delivery system (S-SENDDS) containing Curcumin (CRM) were prepared using combination of Ganoderma lucidium extract powder (GLEP) and probiotics (PB) as carriers. Liquid SNEDDS containing CRM were prepared by mixing Capmul MCM, Labrafil M1944CS, Tween 80 and Transcutol P. These were further spray dried and finally converted into spheroids. The droplet size of reconstituted S-SNEDDS powder and spheroids was found in the range of 35 to 37 nm, zeta potential in the range of - 21.48 to -23.22 mV and drug loading in the range of 95-96%. The release of drug from formulations was found to be more than 90%. Similarly, significant improvement (p   0.05) in drug loading, droplet size, dissolution rate and angle of repose between L-SNEDDS and S-SNEDDS indicated the potential of GLEP-PB to produce stable SNEDDS.
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