Abstract B56: Tissue transglutaminase/Frizzled receptor clusters regulate WNT transcriptional activity in ovarian cancer stem cells

Ovarian cancer (OC) is the most lethal gynecologic cancer, characterized by chemoresistance and fatal tumor recurrence after primary treatment. The metastatic progression and post-chemotherapy recurrence of OC is linked to a small population of cancer stem cells (CSCs) detectable as ALDH+/CD133+ phenotype. In OC, the tumor microenvironment (TME) provides a favorable milieu that protects quiescent CSCs during chemotherapy and supports their...