Daniela Matei
Northwestern University
CancerInternal medicinePathologyOncologyMolecular biologyChemistryDNA methylationImmunologyChemotherapyMetastasisOvarian cancerCarboplatinStem cellPhases of clinical researchEpigeneticsCancer researchClinical trialCancer stem cellMedicineBiologyCancer cellPharmacology
239Publications
59H-index
10.3kCitations
Publications 219
Newest
#1Emma L. Barber (NU: Northwestern University)H-Index: 18
#2Daniela Matei (NU: Northwestern University)H-Index: 59
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#1Juanyong Li (BU: Boston University)H-Index: 2
#1Jing Li (NU: Northwestern University)H-Index: 12
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 7 authors...
Increased aerobic glycolysis is widely considered as a hallmark of cancer. Yet, cancer cell metabolic reprograming during development of therapeutic resistance is under-studied. Here, through high-throughput stimulated Raman scattering imaging and single cell analysis, we found that cisplatin-resistant cells exhibit increased uptake of exogenous fatty acids, accompanied with decreased glucose uptake and de novo lipogenesis, indicating a reprogramming from glucose and glycolysis dependent to fatt...
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#1Monal Patel (NU: Northwestern University)H-Index: 8
#2Yinu Wang (NU: Northwestern University)H-Index: 8
Last. Marcus E. Peter (NU: Northwestern University)H-Index: 92
view all 9 authors...
Numerous micro(mi)RNAs (short noncoding RNAs that negatively regulate gene expression) have been linked to platinum (Pt) sensitivity and resistance in ovarian cancer (OC). miRNA activity occurs when the guide strand of the miRNA, with its seed sequence (pos. 2-7/8), is loaded into the RNA induced silencing complex (RISC) and targets complementary short seed matches in the 39 untranslated region of mRNAs. Toxic seeds, targeting genes critical for cancer cell survival, have been found in tumor sup...
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#1Minghua Zhuge (ZJU: Zhejiang University)H-Index: 1
#1Minghua Zhuge (ZJU: Zhejiang University)H-Index: 1
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 11 authors...
High-sensitivity chemical imaging offers a window to decipher the molecular orchestra inside a living system. Based on vibrational fingerprint signatures, coherent Raman scattering microscopy provides a label-free approach to map biomolecules and drug molecules inside a cell. Yet, by near-infrared (NIR) pulse excitation, the sensitivity is limited to millimolar concentration for endogenous biomolecules. Here, the imaging sensitivity of stimulated Raman scattering (SRS) is significantly boosted f...
1 CitationsSource
#1Monal Patel (NU: Northwestern University)H-Index: 8
#2Ye Wang (NU: Northwestern University)H-Index: 4
Last. Marcus E. Peter (NU: Northwestern University)H-Index: 92
view all 9 authors...
Development of platinum (Pt) resistance is a major barrier to curing ovarian cancer (OC). 6mer seed toxicity is a novel cancer killing mechanism mediated by tumor suppressive miRNAs with a toxic 6mer seed sequence (positions 2-7) through the RNA-induced silencing complex (RISC). The most toxic 6mer seeds are G-rich and kill cells by targeting the 3' untranslated region of genes critical for cell survival. We now show that treatment of OC cells with Pt leads to an increase in RISC-bound miRNAs ca...
1 CitationsSource
#1Yinu Wang (NU: Northwestern University)H-Index: 8
#1Yinu Wang (NU: Northwestern University)H-Index: 4
Last. Daniela Matei (NU: Northwestern University)H-Index: 59
view all 14 authors...
Defining traits of platinum-tolerant cancer cells could expose new treatment vulnerabilities. Here, new markers associated with platinum-tolerant cells and tumors were identified using in vitro and in vivo ovarian cancer (OC) models treated repetitively with carboplatin and validated in human specimens. Platinum-tolerant cells and tumors were enriched in ALDH (+) cells, formed more spheroids, and expressed increased levels of stemness-related transcription factors compared to parental cells. Add...
5 CitationsSource
#1Monal Patel (NU: Northwestern University)H-Index: 8
#2Yinu Wang (NU: Northwestern University)H-Index: 8
Last. Marcus E. Peter (NU: Northwestern University)H-Index: 92
view all 0 authors...
Ovarian cancer remains one of the deadliest gynecologic malignancies affecting women, and development of resistance to platinum remains a major barrier to achieving a cure. Multiple mechanisms have been identified to confer platinum resistance. Numerous microRNAs (miRNAs) have been linked to platinum sensitivity and resistance in ovarian cancer. miRNA activity occurs mainly when the guide strand of the miRNA, with its seed sequence at position 2-7/8, is loaded into the RNA-induced silencing (RIS...
1 CitationsSource
#1Horacio Cardenas (NU: Northwestern University)H-Index: 18
#2Fang Fang (IU: Indiana University)H-Index: 24
Last. Kenneth P. Nephew (IU: Indiana University)H-Index: 70
view all 11 authors...
High-grade serous ovarian cancer (HGSOC) harbours aberrant epigenetic features, including DNA methylation. In this study we delineate pathways and networks altered by DNA methylation and associated...
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#1Zhe Li (Purdue University)H-Index: 3
#2Ran AnH-Index: 10
Last. David D. Nolte (Purdue University)H-Index: 55
view all 8 authors...
Development of an assay to predict response to chemotherapy has remained an elusive goal in cancer research. We report a phenotypic chemosensitivity assay for epithelial ovarian cancer based on Doppler spectroscopy of infrared light scattered from intracellular motions in living three-dimensional tumor biopsy tissue measured in vitro. The study analyzed biospecimens from 20 human patients with epithelial ovarian cancer. Matched primary and metastatic tumor tissues were collected for 3 patients, ...
3 CitationsSource
#1Daniela Matei (NU: Northwestern University)H-Index: 59
#2Kenneth P. Nephew (IU: Indiana University)H-Index: 70
Last. Kenneth P. Nephew (IU: Indiana University)H-Index: 10
view all 2 authors...
Ovarian cancer (OC) is an aggressive epithelial tumor that remains a major cause of cancer morbidity and mortality in women. Epigenetic alterations including DNA methylation and histone modifications are being characterized in OC and have been functionally linked to processes involved in tumor initiation, chemotherapy resistance, cancer stem cell survival, and tumor metastasis. The epigenetic traits of cancer cells and of associated tumor microenvironment components have been shown to promote an...
3 CitationsSource