Comprehensive Analysis of Barrett’s Esophagus: Focused on Carcinogenic Potential for Barrett’s Cancer in Japanese Patients

Published on Aug 1, 2021in Digestive Diseases and Sciences3.199
· DOI :10.1007/S10620-020-06563-1
Kentaro Ishikawa6
Estimated H-index: 6
(Chiba University),
Kenichiro Okimoto12
Estimated H-index: 12
(Chiba University)
+ 15 AuthorsNaoya Kato18
Estimated H-index: 18
(Chiba University)
Barrett’s esophagus (BE) is a precursor of esophageal adenocarcinoma (EAC). Therefore, an accurate diagnosis of BE is important for the subsequent follow-up and early detection of EAC. However, the definitions of BE have not been standardized worldwide; columnar-lined epithelium (CLE) without intestinal metaplasia (IM) and/or  1 cm (Group A) and those without IM and/or < 1 cm (Group B). Malignant potential was assessed using immunochemical staining for p53. Moreover, causative genes were examined using next-generation sequencing (NGS) on ten patients without Helicobacter pylori infection and without atrophic gastritis. Of the 96 patients, 66 were in Group B. The proportion of carcinoma/dysplasia in Group A was significantly higher than that in Group B (26.7% in Group A and 1.5% in Group B; p < 0.01). However, one EAC patient was found in Group B. In the immunostaining study for non-EAC patients, an abnormal expression of p53 was not observed in Group A, whereas p53 loss was observed in three patients (4.6%) in Group B. In the NGS study, a TP53 mutation was found in Group B. CLE without IM and/or < 1 cm has malignant potential. This result suggests that patients with CLE as well as BE need follow-up.
#1Akira Yokoyama (Kyoto University)H-Index: 39
#2Nobuyuki Kakiuchi (Kyoto University)H-Index: 22
Last. Seishi Ogawa (Kyoto University)H-Index: 101
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Clonal expansion in aged normal tissues has been implicated in the development of cancer. However, the chronology and risk dependence of the expansion are poorly understood. Here we intensively sequence 682 micro-scale oesophageal samples and show, in physiologically normal oesophageal epithelia, the progressive age-related expansion of clones that carry mutations in driver genes (predominantly NOTCH1), which is substantially accelerated by alcohol consumption and by smoking. Driver-mutated clon...
#1Matthew D. Stachler (Harvard University)H-Index: 16
Last. Adam J. Bass (Broad Institute)H-Index: 56
view all 16 authors...
Background & Aims Barrett's esophagus (BE) is the greatest risk factor for esophageal adenocarcinoma (EAC), but only a small proportion of patients with BE develop cancer. Biomarkers might be able to identify patients at highest risk of progression. We investigated genomic differences in surveillance biopsies collected from patients whose BE subsequently progressed compared to patients whose disease did not progress. Methods We performed a retrospective case–control study of 24 patients with BE ...
#1Gianmarco Contino (Medical Research Council)H-Index: 19
#2Thomas L. Vaughan (UW: University of Washington)H-Index: 82
Last. Rebecca C. Fitzgerald (Medical Research Council)H-Index: 71
view all 4 authors...
We have recently gained unprecedented insight into genetic factors that determine risk for Barrett's esophagus (BE) and progression to esophageal adenocarcinoma (EA). Next-generation sequencing technologies have allowed us to identify somatic mutations that initiate BE and track genetic changes during development of tumors and invasive cancer. These technologies led to identification of mechanisms of tumorigenesis that challenge the current multistep model of progression to EA. Newer, cost-effec...
#1Mamoun Younes (University of Texas Health Science Center at Houston)H-Index: 48
#2Keith Brown (BCM: Baylor College of Medicine)H-Index: 1
Last. Atilla Ertan (University of Texas Health Science Center at Houston)H-Index: 24
view all 8 authors...
Aims The purpose of this study was to determine prospectively whether p53 protein accumulation in biopsies of Barrett's metaplasia (BM) is a predictor of malignant progression, without relying on dysplasia grading. Methods and results Sections of formalin fixed paraffin embedded tissue from the initial biopsies of 275 patients with BM, who had no high grade dysplasia (HGD) or esophageal adenocarcinoma (EAC), were stained for p53 by immunohistochemistry. Mean follow up was 41 months. p53-positive...
#7David A. Lieberman (OHSU: Oregon Health & Science University)H-Index: 22
Background & Aims Many patients with a irregular Z line , are encountered. These patients, often referred to as patients with Barrett's esophagus (BE), are enrolled in surveillance programs. However, little is known about their risk of high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC). We aimed to determine the incidence of HGD and EAC in patients with irregular Z line with intestinal metaplasia. Methods We performed a prospective, multicenter cohort study of patients who underwent e...
#1K. AltafH-Index: 1
#2Junjie Xiong (Sichuan University)H-Index: 16
Last. A. KaulH-Index: 1
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Background Barrett's oesophagus is a precursor to the development of oesophageal adenocarcinoma. This study sought to clarify the role of genetic, chromosomal and proliferation biomarkers that have been the subjects of multiple studies through meta-analysis. Methods MEDLINE, Embase, PubMed and the Cochrane Library were searched for clinical studies assessing the value of p53, p16, Ki-67 and DNA content abnormalities in Barrett's oesophagus. The main outcome measure was the risk of development of...
#1Margriet R. Timmer (UvA: University of Amsterdam)H-Index: 7
#2Pierre MartinezH-Index: 15
Last. Kausilia K. Krishnadath (UvA: University of Amsterdam)H-Index: 29
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Objective The risk of developing adenocarcinoma in non-dysplastic Barrett9s oesophagus is low and difficult to predict. Accurate tools for risk stratification are needed to increase the efficiency of surveillance. We aimed to develop a prediction model for progression using clinical variables and genetic markers. Methods In a prospective cohort of patients with non-dysplastic Barrett9s oesophagus, we evaluated six molecular markers: p16 , p53 , Her-2/neu , 20q , MYC and aneusomy by DNA fluoresce...
#4Lauren B. Gerson (University of California, Berkeley)H-Index: 15
Barrett’s esophagus (BE) is among the most common conditions encountered by the gastroenterologist. In this document, the American College of Gastroenterology updates its guidance for the best practices in caring for these patients. These guidelines continue to endorse screening of high-risk patient
#3M. Delabastide (CSHL: Cold Spring Harbor Laboratory)H-Index: 2
Next-generation sequencing of endoscopic biopsies identifies ARID1A as a tumor-suppressor gene in Barrett’s esophagus
#1Christine P.J. Caygill (Royal Free Hospital)H-Index: 11
#2Christine RoystonH-Index: 3
Last. Karna Dev BardhanH-Index: 26
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Background and study aims: There is a view that the majority of deaths in patients with Barrett’s esophagus are from causes other than esophageal adenocarcinoma (EAC). The aim of this analysis was to establish the pattern of mortality for a number of causes in patients with Barrett’s esophagus . Patients and methods: This was a single-center prospective cohort study of patients from Rotherham District General Hospital, which is a secondary referral center. The cohort consisted of 1239 patients w...
Cited By1
#1Mamoru Tokunaga (Chiba University)H-Index: 3
#2Kenichiro Okimoto (Chiba University)H-Index: 12
Last. Kazuyuki Matsushita (Chiba University)H-Index: 27
view all 27 authors...
The genetic characteristics of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) in the Japanese population is unclear. This study aims to investigate the genetic characteristics from nondysplastic BE (NDBE) to early EAC in Japan. Clinical information was collected. Moreover, the genetic profile of NDBE without concurrent dysplasia, early EAC, and surrounding BE were also investigated using endoscopic biopsy samples and formalin-fixed, paraffin-embedded specimens from Japanese patient...
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