Germline biallelic Mcm8 variants are associated with early-onset Lynch-like syndrome
Abstract
Lynch syndrome is the most common cause of hereditary colorectal cancer (CRC), and it is characterized by DNA mismatch repair (MMR) deficiency. The term Lynch-like syndrome (LLS) is used for patients with MMR-deficient tumors and neither germline mutation in MLH1, MSH2, MSH6, PMS2, or EPCAM nor MLH1 somatic methylation. Biallelic somatic inactivation or cryptic germline MMR variants undetected during genetic testing have been proposed to be...
Paper Details
Title
Germline biallelic Mcm8 variants are associated with early-onset Lynch-like syndrome
Published Date
Sep 17, 2020
Journal
Volume
5
Issue
18
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