COVID-19: fighting the invisible enemy with microRNAs.

Published on Feb 1, 2021in Expert Review of Anti-infective Therapy3.767
· DOI :10.1080/14787210.2020.1812385
Neeraj Chauhan24
Estimated H-index: 24
(University of Texas at Austin),
Neeraj Chauhan10
Estimated H-index: 10
(University of Texas at Austin)
+ 1 AuthorsMurali M. Yallapu34
Estimated H-index: 34
(University of Texas at Austin)
Sources
Abstract
The novel coronavirus (CoV) disease 2019 (COVID-19) is a viral infection that causes severe acute respiratory syndrome (SARS). It is believed that early reports of COVID-19 cases were noticed in De...
Figures & Tables
Download
References84
Newest
#1Alexandro Guterres (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 14
Last. Mônica R. Gadelha (UFRJ: Federal University of Rio de Janeiro)H-Index: 39
view all 4 authors...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19, a pandemic associated with substantial morbidity and mortality. Despite of this, no vaccine or approved drug is available to eradicate the virus. In this manuscript, we present an alternative study area that may contribute to development of diagnostic biomarkers and therapeutic targets for COVID-19. We analyzed sixty SARS-CoV-2 genomes to identify regions that could work as virus-encoded miRNA seed sp...
10 CitationsSource
#1Rahila Sardar (Jamia Hamdard)H-Index: 4
#2Deepshikha Satish (International Centre for Genetic Engineering and Biotechnology)H-Index: 3
Last. Dinesh Gupta (International Centre for Genetic Engineering and Biotechnology)H-Index: 25
view all 4 authors...
We have performed an integrative analysis of SARS-CoV-2 genome sequences from different countries. Apart from mutational analysis, we have predicted host antiviral miRNAs targeting virus genes, PTMs in the virus proteins and antiviral peptides. A comparison of the analyses with other coronavirus genomes has been performed, wherever possible. Our analysis confirms unique features in the SARS-CoV-2 genomes absent in other evolutionarily related coronavirus family genomes, which presumably confer u...
35 CitationsSource
Travel-related infections with prolonged incubation periods should be considered in febrile patients despite the current epidemiological situation, especially if alternative more frequent diagnoses, such as COVID-19, are not confirmed.
4 CitationsSource
#1Ali Hosseini Rad Sm (University of Otago)H-Index: 1
#2Alexander D. McLellan (University of Otago)H-Index: 30
The SARS-CoV-2 virus is a recently-emerged zoonotic pathogen already well adapted to transmission and replication in humans. Although the mutation rate is limited, recently introduced mutations in SARS-CoV-2 have the potential to alter viral fitness. In addition to amino acid changes, mutations could affect RNA secondary structure critical to viral life cycle, or interfere with sequences targeted by host miRNAs. We have analysed subsets of genomes from SARS-CoV-2 isolates from around the globe a...
19 CitationsSource
#1Müşerref Duygu Saçar Demirci (Abdullah Gül University)H-Index: 7
#1Müşerref Duygu Saçar Demirci (Abdullah Gül University)H-Index: 3
Last. Aysun Adan (Abdullah Gül University)H-Index: 7
view all 2 authors...
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression found in more than 200 diverse organisms. Although it is still not fully established if RNA viruses could generate miRNAs, there are examples of miRNA like sequences from RNA viruses with regulatory functions. In the case of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), there are several mechanisms that would make miRNAs impact the virus, like interfering with viral replication, translation and even modulat...
42 CitationsSource
#1Elif Damla Arisan (GIT: Gebze Institute of Technology)H-Index: 14
#1Elif Damla Arısan (GIT: Gebze Institute of Technology)H-Index: 3
Last. Pinar Uysal-Onganer (University of Westminster)H-Index: 12
view all 7 authors...
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a member of the betacoronavirus family, which causes COVID-19 disease. SARS-CoV-2 pathogenicity in humans leads to increased mortality rates due to alterations of significant pathways, including some resulting in exacerbated inflammatory responses linked to the “cytokine storm” and extensive lung pathology, as well as being linked to a number of comorbidities. Our current study compared five SARS-CoV-2 sequences from different geogr...
21 CitationsSource
#1Noah C. Peeri (University of North Texas Health Science Center)H-Index: 4
#2Nistha Shrestha (University of North Texas Health Science Center)H-Index: 4
Last. Ubydul Haque (University of North Texas Health Science Center)H-Index: 26
view all 10 authors...
To provide an overview of the three major deadly coronaviruses and identify areas for improvement of future preparedness plans, as well as provide a critical assessment of the risk factors and actionable items for stopping their spread, utilizing lessons learned from the first two deadly coronavirus outbreaks, as well as initial reports from the current novel coronavirus (COVID-19) epidemic in Wuhan, China.Utilizing the Centers for Disease Control and Prevention (CDC, USA) website, and a compreh...
518 CitationsSource
#1Lili Ren (Peking Union Medical College)H-Index: 32
#2Ye Ming Wang (Peking Union Medical College)H-Index: 1
Last. Jianwei Wang (Peking Union Medical College)H-Index: 55
view all 36 authors...
BACKGROUND: Human infections with zoonotic coronaviruses (CoVs), including severe acute respiratory syndrome (SARS)-CoV and Middle East respiratory syndrome (MERS)-CoV, have raised great public health concern globally. Here, we report a novel bat-origin CoV causing severe and fatal pneumonia in humans. METHODS: We collected clinical data and bronchoalveolar lavage (BAL) specimens from five patients with severe pneumonia from Jin Yin-tan Hospital of Wuhan, Hubei province, China. Nucleic acids of ...
435 CitationsSource
#1Lei FangH-Index: 13
#2George Karakiulakis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 25
Last. Michael RothH-Index: 59
view all 3 authors...
The most distinctive comorbidities of 32 non-survivors from a group of 52 intensive care unit patients with novel coronavirus disease 2019 (COVID-19) in the study by Xiaobo Yang and colleagues1 were cerebrovascular diseases (22%) and diabetes (22%). Another study2 included 1099 patients with confirmed COVID-19, of whom 173 had severe disease with comorbidities of hypertension (23·7%), diabetes mellitus (16·2%), coronary heart diseases (5·8%), and cerebrovascular disease (2·3%). In a third study,...
1,315 CitationsSource
#1Hongzhou Lu (Fudan University)H-Index: 30
#2Charles W. Stratton (VUMC: Vanderbilt University Medical Center)H-Index: 50
Last. Yi-Wei Tang (CEPHEID)H-Index: 75
view all 3 authors...
: Since December 2019, a total of 41 cases of pneumonia of unknown etiology have been confirmed in Wuhan city, Hubei Province, China. Wuhan city is a major transportation hub with a population of more than 11 million people. Most of the patients visited a local fish and wild animal market last month. At a national press conference held today, Dr. Jianguo Xu, an academician of the Chinese Academy of Engineering, who led a scientific team announced that a new-type coronavirus, tentatively named by...
1,084 CitationsSource
Cited By6
Newest
During a severe infection such as coronavirus disease 2019 (COVID-19), the level of almost all analytes can change, presenting a correlation with disease severity and survival; however, a biomarker cannot be translated into clinical practice for treatment guidance until it is proven to have a significant impact. Several studies have documented the association between COVID-19 severity and circulating levels of C-reactive protein (CRP) and interleukin-6, and the accuracy of the CRP level in predi...
1 CitationsSource
#1Manoj Khokhar (AIIMS: All India Institute of Medical Sciences)H-Index: 5
#2Sojit Tomo (AIIMS: All India Institute of Medical Sciences)H-Index: 5
Last. Purvi Purohit (AIIMS: All India Institute of Medical Sciences)H-Index: 7
view all 0 authors...
Background: Coronavirus disease 2019 is characterized by the elevation of a wide spectrum of inflammatory mediators which are associated with poor disease outcomes. We aimed at an in-silico analysis of regulatory microRNA and their transcription factors (TF) for these inflammatory genes that may help to devise potential therapeutic strategies in the future. Methods: The cytokine regulating immune-expressed genes (CRIEG) were sorted from literature and GEO microarray dataset and their co-differen...
Source
COVID-19 pandemic is caused by betacoronavirus SARS-CoV-2. The genome of this virus is composed of a single strand of RNA with 5′ and 3′-UTR flanking a region of protein-coding ORFs closely resembling cells’ mRNAs. MicroRNAs are endogenous post-transcriptional regulators that target mRNA to modulate protein expression and mediate cellular functions, including antiviral defense. In the present study, we carried out a bioinformatics screening to search for endogenous human microRNAs targeting the ...
Source
#1Mona FaniH-Index: 6
#2Milad Zandi (Tehran University of Medical Sciences)H-Index: 4
Last. Samaneh AbbasiH-Index: 3
view all 5 authors...
Nowadays, the SARS Coronavirus 2 (SARS-CoV-2) infection is recognized as the primary cause of mortality in humans SARS-CoV-2 is transmitted through human-to-human contact and is asymptomatic in most patients In addition to approved vaccines against SARS-CoV-2 infection, miRNAs may also be promising options against this new virus miRNAs are small and noncoding RNAs 18-25 nucleotides in length that target the mRNAs to degrade them or obstruct their translation miRNAs act as an observer in cells Th...
Source
#1Manijeh Mohammadi-Dehcheshmeh (University of Adelaide)H-Index: 10
#1Manijeh Mohammadi-Dehcheshmeh (La Trobe University)
Last. Esmaeil Ebrahimie (University of Adelaide)
view all 6 authors...
Our knowledge of the evolution and the role of untranslated region (UTR) in SARS-CoV-2 pathogenicity is very limited. Leader sequence, originated from UTR, is found at the 5′ ends of all encoded SARS-CoV-2 transcripts, highlighting its importance. Here, evolution of leader sequence was compared between human pathogenic and non-pathogenic coronaviruses. Then, profiling of microRNAs that can inactivate the key UTR regions of coronaviruses was carried out. A distinguished pattern of evolution in le...
Source
#1Iago Carvalho Schultz (UFCSPA: Universidade Federal de Ciências da Saúde de Porto Alegre)H-Index: 2
#2Ana Paula Santin Bertoni (UFCSPA: Universidade Federal de Ciências da Saúde de Porto Alegre)H-Index: 8
Last. Márcia R. Wink (UFCSPA: Universidade Federal de Ciências da Saúde de Porto Alegre)H-Index: 23
view all 3 authors...
In the end of 2019 COVID-19 emerged as a new threat worldwide and this disease present impaired immune system, exacerbated production of inflammatory cytokines, and coagulation disturbs. Mesenchymal stem cell (MSC) derived extracellular vesicles (EVs) have emerged as a therapeutic option due to its intrinsic properties to alleviate inflammatory responses, capable to promote the restoring of injured tissue. EVs contain heterogeneous cargo, including active microRNAs, small noncoding sequences inv...
2 CitationsSource
#1Dan Li (Hunan University)
#2Jianhui Yang (Hunan University)
Last. Kai He (Hunan University)H-Index: 1
view all 10 authors...
MicroRNAs (miRNAs) belong to a class of noncoding RNAs that suppress gene expression by complementary oligonucleotide binding to the sites in target messenger RNAs. Numerous studies have demonstrated that miRNAs play crucial role in virtually all cellular processes of both plants and animals,such as cell growth, cell division, differentiation, proliferation and apoptosis. The study of rice MIR168a has demonstrated for the first time that exogenous plant MIR168a influences cholesterol transport i...
Source
#1Mohammed Sikander (University of Texas at Austin)H-Index: 7
#1Mohammed Sikander (University of Texas at Austin)
Last. Meena Jaggi (University of Texas at Austin)H-Index: 36
view all 9 authors...
COVID-19 is known as one of the deadliest pandemics of the century. The rapid spread of this deadly virus at incredible speed has stunned the planet and poses a challenge to global scientific and medical communities. Patients with COVID-19 are at an increased risk of co-morbidities associated with liver dysfunction and injury. Moreover, hepatotoxicity induced by antiviral therapy is gaining importance and is an area of great concern. Currently, alternatives therapies are being sought to mitigate...
1 CitationsSource
#1Simona GrecoH-Index: 30
#2A MadeH-Index: 1
Last. Fabio MartelliH-Index: 53
view all 6 authors...
COronaVIrus Disease 19 (COVID-19) is caused by the infection of the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2). Although the main clinical manifestations of COVID-19 are respiratory, many patients also display acute myocardial injury and chronic damage to the cardiovascular system. Understanding both direct and indirect damage caused to the heart and the vascular system by SARS-CoV-2 infection is necessary to identify optimal clinical care strategies. The homeostasis of the car...
2 CitationsSource