Commentary: Metabolites released from apoptotic cells act as tissue messengers.

Published on Aug 20, 2020in Frontiers in Immunology5.085
· DOI :10.3389/FIMMU.2020.01878
Chong Zeng (Southern Medical University), Zhongbao Shao + 2 AuthorsFeiyue Xing12
Estimated H-index: 12
(JNU: Jinan University)
#1Caio Abner LeiteH-Index: 12
#2Jose Mauricio Mota (USP: University of São Paulo)H-Index: 16
Last. Ronaldo A. Ribeiro (UFC: Federal University of Ceará)H-Index: 57
view all 17 authors...
Background Previous data have reported that the growth of established tumors may be facilitated by postsepsis disorder through changes in the microenvironment and immune dysfunction. However, the influence of postsepsis disorder in initial carcinogenesis remains elusive. Methods In the present work, the effect of postsepsis on inflammation-induced early carcinogenesis was evaluated in an experimental model of colitis-associated colorectal cancer (CAC). We also analyzed the frequency and role of ...
1 CitationsSource
#1Paula Jaime-Sánchez (Ciba: Ciba Specialty Chemicals)H-Index: 6
#2Iratxe Uranga-Murillo (Ciba: Ciba Specialty Chemicals)H-Index: 2
Last. Julian Pardo (Ciba: Ciba Specialty Chemicals)H-Index: 15
view all 7 authors...
Background Elimination of cancer cells by some stimuli like chemotherapy and radiotherapy activates anticancer immunity after the generation of damage‐associated molecular patterns, a process recently named immunogenic cell death (ICD). Despite the recent advances in cancer immunotherapy, very little is known about the immunological consequences of cell death activated by cytotoxic CD8+ T (Tc) cells on cancer cells, that is, if Tc cells induce ICD on cancer cells and the molecular mechanisms inv...
12 CitationsSource
#1Christopher B. Medina (UVA: University of Virginia)H-Index: 8
#2Parul Mehrotra (UGent: Ghent University)H-Index: 1
Last. Kodi S. RavichandranH-Index: 66
view all 12 authors...
Caspase-dependent apoptosis accounts for approximately 90% of homeostatic cell turnover in the body1, and regulates inflammation, cell proliferation, and tissue regeneration2–4. How apoptotic cells mediate such diverse effects is not fully understood. Here we profiled the apoptotic metabolite secretome and determined its effects on the tissue neighbourhood. We show that apoptotic lymphocytes and macrophages release specific metabolites, while retaining their membrane integrity. A subset of these...
85 CitationsSource
#1Lorenzo Galluzzi (University of Paris)H-Index: 127
#2Ilio Vitale (University of Rome Tor Vergata)H-Index: 47
Last. Guido KroemerH-Index: 254
view all 169 authors...
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As w...
1,584 CitationsSource
#1Shigekazu Nagata (Osaka University)H-Index: 140
#2Masato Tanaka (Tokyo University of Pharmacy and Life Sciences)H-Index: 54
In this Timeline article, Shigekazu Nagata and Masato Tanaka highlight some of the key discoveries that have shaped the field of programmed cell death over the past 50 years and explain their relevance for the immune system.
161 CitationsSource
#1Lorenzo GalluzziH-Index: 127
#2Aitziber BuquéH-Index: 23
Last. Guido KroemerH-Index: 254
view all 5 authors...
Initiation of an adaptive immune response depends on the detection of both antigenic epitopes and adjuvant signals. Infectious pathogens and cancer cells often avoid immune detection by limiting the release of danger signals from dying cells. When is cell death immunogenic and what are the pathophysiological implications of this process?
960 CitationsSource
#1Peter VandenabeeleH-Index: 153
#2Katrien Vandecasteele (UGent: Ghent University)H-Index: 4
Last. Dmitri V. KryskoH-Index: 47
view all 5 authors...
For many years it has been thought that apoptotic cells rapidly cleared by phagocytic cells do not trigger an immune response but rather have anti-inflammatory properties. However, accumulating experimental data indicate that certain anticancer therapies can induce an immunogenic form of apoptosis associated with the emission of damage-associated molecular patterns (DAMPs), which function as adjuvants to activate host antitumor immune responses. In this review, we will first discuss recent advan...
56 CitationsSource
#1Isabelle Martins (University of Paris-Sud)H-Index: 34
#2Wang Y (University of Paris-Sud)H-Index: 2
Last. Guido KroemerH-Index: 254
view all 12 authors...
The immunogenic demise of cancer cells can be induced by various chemotherapeutics, such as anthracyclines and oxaliplatin, and provokes an immune response against tumor-associated antigens. Thus, immunogenic cell death (ICD)-inducing antineoplastic agents stimulate a tumor-specific immune response that determines the long-term success of therapy. The release of ATP from dying cells constitutes one of the three major hallmarks of ICD and occurs independently of the two others, namely, the pre-ap...
253 CitationsSource
#1Faraaz B. Chekeni (UVA: University of Virginia)H-Index: 5
#2Michael R. Elliott (UVA: University of Virginia)H-Index: 51
Last. Kodi S. Ravichandran (UVA: University of Virginia)H-Index: 66
view all 13 authors...
Apoptotic cells discharge ATP and UTP, which act as 'find-me' signals for phagocytes that in turn engulf dying cells before potentially harmful cellular contents are released. These authors show that the release of ATP and UTP is exclusively by means of the plasma membrane channel pannexin 1, which is opened specifically by caspase activity.
737 CitationsSource
#1Michael R. Elliott (Carter Center)H-Index: 51
#2Faraaz B. Chekeni (Carter Center)H-Index: 5
Last. Kodi S. Ravichandran (UVA: University of Virginia)H-Index: 66
view all 14 authors...
The efficient removal of apoptotic cells in vivo is thought to be due to the release of 'find-me' signals by apoptotic cells that recruit motile phagocytes. Here, the caspase-dependent release of ATP and UTP during the early stages of apoptosis is demonstrated. ATP and UTP are found to act as chemoattractants in a process mediated through the ATP/UTP receptor P2Y2, which is present on monocytes and macrophages.
1,007 CitationsSource
Cited By0