Feiyue Xing
Jinan University
Atomic force microscopyCytotoxicityCellMolecular biologyNotch signaling pathwayGene knockdownJurkat cellsChemistryApoptosisIn vitroImmunologyT cellAnisomycinDendritic cellEnosLipopolysaccharideCell cycleCancer researchBiochemistryCell growthSignal transductionIL-2 receptorBiologyCell biology
29Publications
12H-index
301Citations
Publications 28
Newest
#1Boning Zeng (JNU: Jinan University)H-Index: 3
#2Zhenlong Cai (JNU: Jinan University)
Last. Feiyue Xing (JNU: Jinan University)H-Index: 12
view all 8 authors...
Abstract Photoinitiators (PIs) are widely used for photopolymerization in industrial area and recently paid close attention to in biomedical field. However, there are few reports on their toxicity to human health. Here we explored cytotoxicity and cytocompatibilty of seven commercial and industrial-used PIs for developing their potential clinical application. Phenylbis(acyl) phosphine oxides (BAPO), 2-Benzyl-2-(dimethylamino)-4′-morpholinobutyrophenone (369), 4,4’-Bis(diethylamino) benzophenone ...
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#1Chong Zeng (Southern Medical University)
Last. Feiyue Xing (JNU: Jinan University)H-Index: 12
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#1Zhengle Tang (JNU: Jinan University)H-Index: 2
#2Yuan Wang (JNU: Jinan University)H-Index: 2
Last. Feiyue Xing (JNU: Jinan University)H-Index: 12
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Abstract CSL(CBF1, Su(H) and LAG-1)-dependent Hes-1 signaling plays an important part in regulating Th17 cell differentiation. However, little is known about influence of CSL-independent Deltex-1 signaling on this subset. The current focus is on roles of the Deltex-1 signaling in the Th17 cell differentiation. IL-17-producing CD4+ T cell subpopulation could be induced in vitro by treatment of both IL-6 and TGF-β. This could be reversed by knockdown of the deltex-1 gene, following the attenuation...
1 CitationsSource
#1Boning Zeng (JNU: Jinan University)H-Index: 3
#2Shengnan Shi (JNU: Jinan University)H-Index: 2
Last. Feiyue Xing (JNU: Jinan University)H-Index: 12
view all 6 authors...
Inflammatory bowel diseases (IBD), composed mainly of Crohn’s disease (CD) and ulcerative colitis (UC), are strongly implicated in the development of intestinal inflammation lesions. Its exact etiology and pathogenesis are still undetermined. Recently accumulating evidence supports that group 3 innate lymphoid cells (ILC3) are responsible for gastrointestinal mucosal homeostasis through moderate generation of IL-22, IL-17, and GM-CSF in the physiological state. ILC3 contribute to the progression...
53 CitationsSource
#1Haifeng Fu (JNU: Jinan University)H-Index: 1
#2Feiyue Xing (JNU: Jinan University)H-Index: 12
Last. Jing Liu (JNU: Jinan University)H-Index: 8
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Abstract The Notch signaling pathway plays a key role in cell proliferation and development that is closely related to an inverted CCAAT box binding protein (ICBP90), but little is known about whether there is a correlation between Notch signaling and ICBP90. The aim of the current study was to elucidate this. MTT assay and flow cytometry were used to determine the proliferation, cell cycle and apoptosis of HepG2 or Hepa1-6 cells treated by N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine...
1 CitationsSource
#1Boning Zeng (JNU: Jinan University)H-Index: 3
#2Shengnan Shi (JNU: Jinan University)H-Index: 2
Last. Feiyue Xing (JNU: Jinan University)H-Index: 12
view all 4 authors...
7 CitationsSource
#1Yi Lv (JNU: Jinan University)H-Index: 7
#2Jia Xiao (JNU: Jinan University)H-Index: 18
Last. Feiyue Xing (JNU: Jinan University)H-Index: 12
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: E2F transcriptional factors are widely expressed in a number of tissues and organs, possessing many regulatory functions related to cellular proliferation, differentiation, DNA repair, cell-cycle and cell apoptosis. E2F8 is a recently identified member of the E2F family with a duplicated DNA-binding domain feature discriminated from E2F1-6, controlling gene expression in a dimerization partner-independent manner. It is indispensable for angiogenesis, lymphangiogenesis and embryonic development...
17 CitationsSource
#1Zhiwei ZhouH-Index: 2
#2Xijian LuH-Index: 2
Last. Feiyue Xing (JNU: Jinan University)H-Index: 12
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Anisomycin, an antibiotic produced by Streptomyces griseolus, strongly induces apoptosis in various tumor cells in vitro, superior dramatically to adriamycin. The present study aims to elucidate its detailed mechanistic process. The results showed that anisomycin sufficiently promoted the apoptosis in human leukemic Jurkat T cells at a quite low dose. microRNA let-7c (let-7c) contributed to the anisomycin-induced apoptosis, which could be abrogated by the inactivation of JNK signaling. The let-7...
12 CitationsSource
#1Chong Zeng (JNU: Jinan University)H-Index: 2
#2Rui Xing (THU: Tsinghua University)H-Index: 1
Last. Feiyue Xing (JNU: Jinan University)H-Index: 12
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Apoptosis is a normally biological phenomenon in various organisms, involving complexly molecular mechanisms with a series of signaling processes. Notch signaling is found evolutionarily conserved in many species, playing a critical role in embryonic development, normal tissue homeostasis, angiogenesis and immunoregulation. The focus of this review is on currently novel advances about roles of CSL-dependent and independent Notch signaling pathways in cell apoptosis. The CSL can bind Notch intrac...
24 CitationsSource
#1Yu Xia (JNU: Jinan University)H-Index: 1
#2Pengtao You (JNU: Jinan University)H-Index: 3
Last. Feiyue Xing (JNU: Jinan University)H-Index: 12
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Selenium nanoparticles loaded with an anticancer molecule offer a new strategy for cancer treatment. In the current study, anisomycin-loaded functionalized selenium nanoparticles (SeNPs@Am) have been made by conjugating anisomycin to the surface of selenium nanoparticles to improve anticancer efficacy. The prepared nanoparticles were fully characterized by transmission electronic microscopy, energy dispersive X-ray spectroscopy, Fourier-transformed infrared spectroscopy, and X-ray photoelectron ...
42 CitationsSource