Original paper
Yeast ATM and ATR kinases use different mechanisms to spread histone H2A phosphorylation around a DNA double-strand break
Volume: 117, Issue: 35, Pages: 21354 - 21363
Published: Aug 17, 2020
Abstract
Significance Creation of a chromosomal double-strand break (DSB) is rapidly accompanied by extensive phosphorylation of yeast histone H2A isoform (H2AX in mammals) by Mec1 (ATR) and Tel1 (ATM) protein kinases. This phosphorylation, termed γ-H2AX, spreads 50 kb on either of the DSB, but how this phosphorylation is propagated is poorly understood. We have monitored the kinetics and extent of spreading individually for Mec1 and Tel1 and find that...
Paper Details
Title
Yeast ATM and ATR kinases use different mechanisms to spread histone H2A phosphorylation around a DNA double-strand break
Published Date
Aug 17, 2020
Volume
117
Issue
35
Pages
21354 - 21363