Original paper
Abstract 6506: Targeting ATM with AZD1390 for radio-sensitization of glioblastoma patient derived xenografts
Abstract
The efficacy of standard radiation therapy (RT) in glioblastoma (GBM) is limited, and there is a strong rationale to develop effective radiosensitizing agents. ATM is a key regulator of DNA damage induced by RT, and small molecule ATM inhibitors have shown radio-sensitizing effects in cancer cells, and may improve radio-sensitivity in GBM. Here, we evaluated the brain penetrant ATM inhibitor AZD1390 in combination with RT in GBM cell lines and...
Paper Details
Title
Abstract 6506: Targeting ATM with AZD1390 for radio-sensitization of glioblastoma patient derived xenografts
Published Date
Aug 15, 2020
Journal
Volume
80
Issue
16_Supplement
Pages
6506 - 6506
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Notes
History