Immunomodulatory therapeutics, which is conducive to overcoming tumor tolerance and restoring normal immune responses, has been proposed as a promising approach for enhanced cancer therapy and clin...
Last. Yuxia Luan(SDU: Shandong University)H-Index: 31
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Abstract An efficient antitumor immune response relies on multiple cells-based process including tumor cells-targeted immunogenicity increment, dendritic cells (DCs)-targeted vaccine delivery and T cells-mediated tumor elimination. Only limited immune efficacy could be achieved by strengthening the function of single type of cells. Therefore, building an effective immunotherapeutic nanoplatform by simultaneously modulating the functions of multiple cells involved in immune process is urgently de...
Various subtypes of immunocytes react against implanted biomaterials to eliminate the foreign body object from the host’s body. Among these cells, dendritic cells (DCs) play a key role in early imm...
Abstract Inducible T-cell costimulator (ICOS) upon binding to its ligand (ICOSL) mediates adaptive immunity and antitumor response. Thus, antitumor therapies targeting the ICOS/ICOSL pathway hold great promise for cancer treatment. In this regard, ICOSL triggering by a soluble recombinant form of ICOS (ICOS-Fc) hampered adhesiveness and migration of dendritic, endothelial, and tumor cells in vitro. Furthermore, in vivo treatment with ICOS-Fc previously showed the capability to inhibit lung metas...
Breast cancer is the leading cause of cancer-related mortality among women. Early-stage diagnosis and treatment of this cancer are crucial to patients’ survival. Besides, it is important to avoid severe side effects during the process of conventional treatments (surgery, chemotherapy, hormonal therapy, and targeted therapy) and increase the patients’ quality of life. Over the past decade, nanomaterials of all kinds have shown excellent prospects in different aspects of oncology. Among them, two-...
Last. Daniel Olive(AMU: Aix-Marseille University)H-Index: 78
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AbstractIntroduction: The promotion of antitumor response by targeting co-stimulatory B7 superfamily members has become evident to create a new wave of cancer immunotherapy. Inducible Co-Stimulator...
The use of targeted liposomes encapsulating chemotherapy drugs enhances the specific targeting of cancer cells, thus reducing the side effects of these drugs and providing patient-friendly chemotherapy treatment. Targeted pegylated (stealth) liposomes have the ability to safely deliver their loaded drugs to the cancer cells by targeting specific receptors overly expressed on the surface of these cells. Applying ultrasound as an external stimulus will safely trigger drug release from these liposo...
#1Shuya Li(USTC: University of Science and Technology of China)H-Index: 8
#2Qin Wang(USTC: University of Science and Technology of China)H-Index: 7
Last. Yucai Wang(USTC: University of Science and Technology of China)H-Index: 54
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Myeloid-derived suppressor cells (MDSCs) promote tumor immune escape through multiple mechanisms including suppressing antitumor activities of T lymphocytes. However, therapeutic abrogation of MDSCs often causes severe adverse effects, compensatory recruitment of alternative cell populations, and the multiplicity and complexity of relevant cytokines/receptors. Alternatively, suppressing the expansion and tumor trafficking of MDSCs may be a proficient and safe way for cancer treatment. Here we re...
Last. Nianping Feng(SHU: Shanghai University)H-Index: 27
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Abstract Cancer is a leading cause of mortality worldwide. Cell membrane-coated nanocarriers actively targeting tumor sites are known to circumvent the limitations of conventional treatments and nanosized drug delivery systems. Cell membrane-coated nanocarriers can evade the immune system and can target tumors, thereby exhibiting a prolonged circulation time, enhancing tumor accumulation, increasing cancer therapeutic efficacy, and facilitating tumor imaging in vivo. Numerous studies have focuse...
Last. Jun Huang(USYD: University of Sydney)H-Index: 63
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Abstract Recent advances in nanomedicine make it auspicious for cancer diagnosis and treatment. A possible non-invasive photothermal therapy (PTT) for cancer treatment could be constructed by combining the nanomedicine and laser. PTT employs photothermal agents (PTAs) with high photothermal conversion efficacy for converting light into heat to selectively kill cancer cells under the help of lasers. Because of the unique Surface Plasmon Resonance (SPR) phenomenon and the tunable near-infrared (NI...
Photodynamic therapy (PDT) is a noninvasive and effective local treatment for cancers that produces selective damage to target tissues and cells. However, PDT alone is unlikely to completely inhibit tumor metastasis and/or local tumor recurrence. RNA interference (RNAi) is a phenomenon of gene silencing mediated by exogenous or endogenous double-stranded RNA (dsRNA). RNAi has entered a golden period of development, with the approval of four treatments employing RNAi. PDT in combination with RNAi...
Vaccines are considered one of the most significant medical advancements in human history, as they have prevented hundreds of millions of deaths since their discovery; however, modern travel permits disease spread at unprecedented rates, and vaccine shortcomings like thermal sensitivity and required booster shots have been made evident by the COVID-19 pandemic. Approaches to overcoming these issues appear promising via the integration of vaccine technology with biomaterials, which offer sustaine...
#2Katarzyna Staszak(PUT: Poznań University of Technology)H-Index: 14
Last. Stefan Jurga(Adam Mickiewicz University in Poznań)H-Index: 33
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Abstract This review presents the latest innovations and trends in the field of surface functionalization of various nanomaterials. The most recent protocols of smart materials fabrication as well as the main challenges which should be overcome in order to improve their final performance are discussed here. Particular attention has been paid to the properties improvement of polymer, silica, inorganic and hybrid nanomaterials and their potential for application in many fields, from industry, mate...
Last. Ya Liu(Ocean University of China)H-Index: 21
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Abstract In recent years, with the continuous development of cancer immunotherapy, the strategy of human beings against cancer has undergone tremendous changes. Among them, immune checkpoint inhibitors based on the immune "brake" mechanism, as an indispensable part of immunotherapy, have brought new dawn to cancer treatment. Humans have developed a variety of monoclonal antibodies against CTLA-4 and PD-1/PD-L1, which have shown significant therapeutic effects on various cancers, especially melan...
#2Jingyun Wang(DUT: Dalian University of Technology)H-Index: 40
Last. Qixian Chen(DUT: Dalian University of Technology)H-Index: 23
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In light of immune facilities trafficking toward the pathological sites along upward gradient of immunostimulatory cytokines, a localized resiquimod (Toll-like receptor 7/8 agonist) release depot was manufactured for pursuit of precision immunostimulation toward intractable triple-negative breast carcinoma. In principle, resiquimod/poly(lactic-co-glycolic acid) microspheres were fabricated and embedded into injectable and biodegradable poly(ethylene glycol) (PEG)-based hydrogel. The subsequent i...
#1David G. Calatayud(CSIC: Spanish National Research Council)H-Index: 12
#2Teresa Jardiel(CSIC: Spanish National Research Council)H-Index: 16
Last. P. Arévalo(Complutense University of Madrid)H-Index: 4
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Existing fluorescent labels used in life sciences are based on organic compounds with limited lifetime or on quantum dots which are either expensive or toxic and have low kinetic stability in biological environments. To address these challenges, luminescent nanomaterials have been conceived as hierarchical, core-shell structures with spherical morphology and highly controlled dimensions. These tailor-made nanophosphors incorporate Ln:YVO4 nanoparticles (Ln = Eu(III) and Er(III)) as 50 nm cores a...
#1Anthony Brouillard(UMass: University of Massachusetts Amherst)H-Index: 3
#2Nilesh Deshpande(UMass: University of Massachusetts Amherst)H-Index: 1
Last. Ashish Kulkarni(UMass: University of Massachusetts Amherst)H-Index: 18
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Cancer immunotherapy is set to emerge as the future of cancer therapy. However, recent immunotherapy trials in different cancers have yielded sub-optimal results, with durable responses seen in only a small fraction of patients. Engineered multifunctional nanomaterials and biological materials are versatile platforms that can elicit strong immune responses and improve anti-cancer efficacy when applied to cancer immunotherapy. While there are traditional systems such as polymer- and lipid-based n...