Notch signaling contributes to the establishment of sustained unresponsiveness to food allergens by oral immunotherapy

BackgroundOral immunotherapy (OIT) aims to establish desensitization and sustained unresponsiveness (SU) in patients with food allergy by ingestion of gradually increasing doses of specific food allergens. However, little is known about the mechanisms by which OIT induces SU to specific allergens.ObjectivesWe investigated the role of Notch signaling, which controls cell fate decisions in many types of immune cells in the induction of SU by OIT...