Nobuhiro Nakano
Juntendo University
PromoterGeneInterleukin 33Chromatin immunoprecipitationImmunoglobulin EMolecular biologyAntibodyNotch signaling pathwayRegulation of gene expressionReceptorGene knockdownElectrophoretic mobility shift assayChemistryStem cell factorImmunologyCIITACytokineMHC class IIMast cellTranscription (biology)DegranulationCancer researchTranscription factorBiologyCell biology
Publications 63
#1Saaya Fukase (Juntendo University)H-Index: 1
#2Tomoaki Ando (Juntendo University)H-Index: 11
Last. Nobuhiro Nakano (Juntendo University)H-Index: 20
view all 0 authors...
Abstract null null Purpose null We aimed to clarify the role of particulate allergen exposure to the conjunctiva in the development of allergic conjunctivitis. null null null Methods null We administered ragweed pollen suspension, pollen extract, pollen shell, particulate air pollutants, and their combinations to the mouse conjunctiva five days a week without prior sensitization. Clinical signs were scored. Histological changes, cellular infiltrations, mRNA expressions, lymph node cell recall re...
#1Nutda Sutthammikorn (CMU: Chiang Mai University)
#5Sunee Chansakaow (CMU: Chiang Mai University)H-Index: 8
Last. Ko Okumura (Juntendo University)H-Index: 159
view all 12 authors...
Nonhealing wounds are major socioeconomic challenges to healthcare systems worldwide. Therefore, there is a substantially unmet need to develop new drugs for wound healing. Gynura procumbens, a herb found in Southeast Asia, may be an effective therapeutic for nonhealing diabetic wounds. The aim of this study was to evaluate the efficacy of G. procumbens on wound healing in the diabetic milieu. G. procumbens extract was obtained using 95% ethanol and its components were determined by thin layer c...
#1Hiroki YasudoH-Index: 4
#2Taiki Ando (Juntendo University)H-Index: 2
Last. Jiro Kitaura (Juntendo University)H-Index: 37
view all 28 authors...
The nucleotide-binding domain leucine-rich repeat (LRR)-containing protein family pyrin domain (PYD)-containing protein 1 (NLRP1) forms an inflammasome complex with apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and caspase-1. Inflammasome-activated caspase-1 cleaves pro-IL-1β or pro-IL-18 to produce its mature form and induces a type of cell death called pyroptosis through gasdermin D (GSDMD) activation.
#1Toshiyuki Yoneyama (Juntendo University)H-Index: 2
#2Nobuhiro Nakano (Juntendo University)H-Index: 20
Last. Toshiaki Shimizu (Juntendo University)H-Index: 41
view all 13 authors...
ABSTRACT Background Oral immunotherapy (OIT) aims to establish desensitization and sustained unresponsiveness (SU) in food allergy patients by ingesting gradually increasing doses of specific food allergens. However, little is known about the mechanisms by which OIT induces SU to specific allergens. Objectives We investigated the role of Notch signaling, which controls cell fate decisions in many immune cell types, in the induction of SU by OIT treatment. Methods Two types of mouse models, ovalb...
4 CitationsSource
#1Kumi Izawa (Juntendo University)H-Index: 10
#2Ayako Kaitani (Juntendo University)H-Index: 10
Last. Jiro Kitaura (Juntendo University)H-Index: 37
view all 27 authors...
4 CitationsSource
#1Shino Uchida (Juntendo University)H-Index: 4
#2Kumi Izawa (Juntendo University)H-Index: 10
Last. Jiro Kitaura (Juntendo University)H-Index: 37
view all 19 authors...
6 CitationsSource
#1Tomonobu Ito (TMU: Tokyo Medical University)H-Index: 11
#2Chizu Egusa (TMU: Tokyo Medical University)H-Index: 5
Last. Ryoji Tsuboi (TMU: Tokyo Medical University)H-Index: 48
view all 7 authors...
#1Ayako Takamori (Juntendo University)H-Index: 4
#2Kumi Izawa (Juntendo University)H-Index: 10
Last. Jiro Kitaura (Juntendo University)H-Index: 37
view all 26 authors...
Ceramide-CD300f binding inhibits mouse Mrgprb2 (human MrgprX2)-mediated mast cell activation, thereby suppressing pseudo-allergic reactions. CD300f could be a therapeutic target against IgE-independent pseudo-allergy as well as IgE-dependent allergy.
8 CitationsSource
#1Ayako Kaitani (Juntendo University)H-Index: 10
#2Kumi Izawa (Juntendo University)H-Index: 10
Last. Jiro Kitaura (Juntendo University)H-Index: 37
view all 22 authors...
Plasmacytoid dendritic cells (pDCs) produce large amounts of type-I interferon (IFN) in response to viral infection or self nucleic acids. Leukocyte mono-immunoglobulin-like receptor 8 (LMIR8), also called CMRF-35-like molecule-6 (CLM-6), is a putative activating receptor among mouse LMIR/CLM/CD300 members; however, the expression and function of LMIR8 remain unclear. Here, we characterize mouse LMIR8 as a pDC receptor. Analysis of Flag-tagged LMIR8-transduced bone marrow (BM)-derived mast cells...
4 CitationsSource
#1Masamichi Isobe (Juntendo University)H-Index: 5
#2Kumi Izawa (Juntendo University)H-Index: 10
Last. Jiro Kitaura (Juntendo University)H-Index: 37
view all 22 authors...
: CD300 molecules (CD300s) belong to paired activating and inhibitory receptor families, which mediate immune responses. Human CD300e (hCD300e) is expressed in monocytes and myeloid dendritic cells and transmits an immune-activating signal by interacting with DNAX-activating protein 12 (DAP12). However, the CD300e ortholog in mice (mCD300e) is poorly characterized. Here, we found that mCD300e is also an immune-activating receptor. We found that mCD300e engagement triggers cytokine production in ...
7 CitationsSource