Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis
Abstract
Ironing out a survival strategy Metastatic cells display a notable ability to adapt to—and even thrive in—harsh microenvironments. One extreme example is leptomeningeal metastases (LM), cancer cells that enter a region of the central nervous system called the subarachnoid space, which is filled with cerebral spinal fluid (CSF). This anatomic site has a limited supply of micronutrients such as iron, and it harbors immune cells. Chi et al. used...
Paper Details
Title
Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis
Published Date
Jul 17, 2020
Journal
Volume
369
Issue
6501
Pages
276 - 282
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Notes
History