Interaction between Alcohol Consumption and Apolipoprotein E (ApoE) Genotype with Cognition in Middle-Aged Men.

Published on Jan 1, 2021in Journal of The International Neuropsychological Society2.576
· DOI :10.1017/S1355617720000570
Riki E Slayday (SDSU: San Diego State University), Daniel E. Gustavson16
Estimated H-index: 16
(UCSD: University of California, San Diego)
+ 11 AuthorsCarol E. Franz48
Estimated H-index: 48
(UCSD: University of California, San Diego)
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Abstract
OBJECTIVE Heavy alcohol consumption is associated with poorer cognitive function in older adults. Although understudied in middle-aged adults, the relationship between alcohol and cognition may also be influenced by genetics such as the apolipoprotein (ApoE) e4 allele, a risk factor for Alzheimer's disease. We examined the relationship between alcohol consumption, ApoE genotype, and cognition in middle-aged adults and hypothesized that light and/or moderate drinkers (≤2 drinks per day) would show better cognitive performance than heavy drinkers or non-drinkers. Additionally, we hypothesized that the association between alcohol use and cognitive function would differ by ApoE genotype (e4+ vs. e4-). METHOD Participants were 1266 men from the Vietnam Era Twin Study of Aging (VETSA; M age = 56; range 51-60) who completed a neuropsychological battery assessing seven cognitive abilities: general cognitive ability (GCA), episodic memory, processing speed, executive function, abstract reasoning, verbal fluency, and visuospatial ability. Alcohol consumption was categorized into five groups: never, former, light, moderate, and heavy. RESULTS In fully adjusted models, there was no significant main effect of alcohol consumption on cognitive functions. However, there was a significant interaction between alcohol consumption and ApoE e4 status for GCA and episodic memory, such that the relationship of alcohol consumption and cognition was stronger in e4 carriers. The e4+ heavy drinking subgroup had the poorest GCA and episodic memory. CONCLUSIONS Presence of the e4 allele may increase vulnerability to the deleterious effects of heavy alcohol consumption. Beneficial effects of light or moderate alcohol consumption were not observed.
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