Original paper
Microsatellite instability in cancer: a novel landscape for diagnostic and therapeutic approach
Abstract
Defective DNA mismatch repair creates a strong mutator phenotype, recognized as microsatellite instability (MSI). Various next-generation sequencing-based methods for evaluating cancer MSI status have been established, and NGS-based studies have thoroughly described MSI-driven tumorigenesis. Accordingly, high-frequency MSI (MSI-H) has been detected in 81 tumor types, including those in which MSI was previously underrated. The findings have...
Paper Details
Title
Microsatellite instability in cancer: a novel landscape for diagnostic and therapeutic approach
Published Date
Jul 6, 2020
Journal
Volume
94
Issue
10
Pages
3349 - 3357
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Notes
History