Archives of Toxicology
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5.15
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7,112
Papers 7,377
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#1Erica Selin (SLU: Swedish University of Agricultural Sciences)H-Index: 1
#2Geeta Mandava (SLU: Swedish University of Agricultural Sciences)H-Index: 4
Last. Johan Lundqvist (SLU: Swedish University of Agricultural Sciences)H-Index: 14
view all 5 authors...
Liquid smoke products are widely used as a food additive to create a desired smoke flavour. These products may contain hazardous chemicals generated during the wood-burning process. However, the toxic effects of these types of hazardous chemicals constituting in the commercially available products are largely unknown. Therefore, a test battery of cell-based in vitro methods, covering different modes of actions of high relevance to human health, was applied to study liquid smoke products. Ten liq...
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#1Omar Sheikh (U of A: University of Alberta)H-Index: 2
#2Toshifumi Yokota (U of A: University of Alberta)H-Index: 34
Duchenne muscular dystrophy (DMD) afflicts 1 in 5000 newborn males, leading to progressive muscle weakening and the loss of ambulation between the ages of 8 and 12. Typically, DMD patients pass away from heart failure or respiratory failure. Currently, there is no cure, though exon-skipping therapy including eteplirsen (brand name Exondys 51), a synthetic antisense oligonucleotide designed to skip exon 51 of the dystrophin gene, is considered especially promising. Applicable to approximately 14%...
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#1Jiang Ma (CUHK: The Chinese University of Hong Kong)H-Index: 10
#2Chunyuan Zhang (CUHK: The Chinese University of Hong Kong)H-Index: 6
Last. Ge Lin (CUHK: The Chinese University of Hong Kong)H-Index: 57
view all 5 authors...
Pyrrolizidine alkaloids (PAs) are phytotoxins widely present in various natural products and foodstuffs. The present study aims to investigate the effects of fasting on PA-induced hepatotoxicity and the underlying biochemical mechanisms. The results of hepatotoxic study showed that 15-h overnight fasting significantly exacerbated the hepatotoxicity of retrorsine (RTS, a representative toxic PA) in fasted rats compared to fed rats, as indicated by remarkably elevated plasma ALT and bilirubin leve...
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#1Sandra Andriamasinoro (UdeM: Université de Montréal)
#2Denis Dieme (UdeM: Université de Montréal)H-Index: 3
Last. Michèle Bouchard (UdeM: Université de Montréal)H-Index: 26
view all 7 authors...
Silver nanoparticles (Ag NPs) are priority substances closely monitored by health and safety agencies. Despite their extensive use, some aspects of their toxicokinetics remain to be documented, in particular following inhalation, the predominant route of exposure in the workplace. A same experimental protocol and exposure conditions were reproduced two times (experiments E1 and E2) to document the kinetic time courses of inhaled Ag NPs. Rats were exposed nose-only to 20 nm Ag NPs during 6 h at a...
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#1Fan Hu (Hefei University of Technology)H-Index: 2
#2Guangwei Xu (USTC: University of Science and Technology of China)H-Index: 3
Last. Yifeng Zhou (CAS: Chinese Academy of Sciences)H-Index: 33
view all 7 authors...
Contrast perception is a fundamental visual ability that allows us to distinguish objects from the background. However, whether it is perturbed by chronic exposure to environmental xenoestrogen, bisphenol A (BPA), is still elusive. Here, we used adult cats to explore BPA-induced changes in contrast sensitivity (CS) and its underlying neuronal coding mechanism. Behavioral results showed that 14 days of BPA exposure (0.4 mg/kg/day) was sufficient to induce CS declines at the tested spatial frequen...
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#1Carmen Estevan (Universidad Miguel Hernández de Elche)H-Index: 8
#2Eugenio Vilanova (Universidad Miguel Hernández de Elche)H-Index: 22
Last. Miguel A. Sogorb (Universidad Miguel Hernández de Elche)H-Index: 20
view all 3 authors...
The world is living a pandemic situation derived from the worldwide spreading of SARS-CoV-2 virus causing COVID-19. Facemasks have proven to be one of the most effective prophylactic measures to avoid the infection that has made that wearing of facemasks has become mandatory in most of the developed countries. Silver and graphene nanoparticles have proven to have antimicrobial properties and are used as coating of these facemasks to increase the effectivity of the textile fibres. In the case of ...
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#1Carmine S. Leggett (University of Louisville)
#2Mark A. Doll (University of Louisville)H-Index: 46
Last. David W. Hein (University of Louisville)H-Index: 67
view all 6 authors...
Arylamine N-acetyltransferase 1 (NAT1) plays a pivotal role in the metabolism of carcinogens and is a drug target for cancer prevention and/or treatment. A protein–ligand virtual screening of 2 million chemicals was ranked for predicted binding affinity towards the inhibition of human NAT1. Sixty of the five hundred top-ranked compounds were tested experimentally for inhibition of recombinant human NAT1 and N-acetyltransferase 2 (NAT2). The most promising compound 9,10-dihydro-9,10-dioxo-1,2-ant...
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#1Jimmy Alarcan (BfR: Federal Institute for Risk Assessment)H-Index: 5
#2Georges de Sousa (CNRS: Centre national de la recherche scientifique)H-Index: 1
Last. Dajana Lichtenstein (BfR: Federal Institute for Risk Assessment)H-Index: 14
view all 10 authors...
Within the EuroMix project, we have previously developed an adverse outcome pathway (AOP)-based in vitro assay toolbox to investigate the combined effects of liver steatosis-inducing compounds in human HepaRG hepatocarcinoma cells. In this study, we applied the toolbox to further investigate mixture effects of combinations, featuring either similarly acting or dissimilarly acting substances. The valproic acid structural analogs 2-propylheptanoic acid (PHP) and 2-propylhexanoic acid (PHX) were ch...
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#2Franz WorekH-Index: 56
Last. Timo WilleH-Index: 19
view all 4 authors...
Organophosphorus compound pesticides (OP) are widely used in pest control and might be misused for terrorist attacks. Although acetylcholinesterase (AChE) inhibition is the predominant toxic mechanism, OP may induce pneumonia and formation of lung edema after poisoning and during clinical treatment as life-threatening complication. To investigate the underlying mechanisms, rat precision-cut lung slices (PCLS) were exposed to the OP parathion, malathion and their biotransformation products paraox...
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#1Gabriele Sabbioni (LMU: Ludwig Maximilian University of Munich)H-Index: 25
#2Billy W. DayH-Index: 62
Chemicals are measured regularly in air, food, the environment, and the workplace. Biomonitoring of chemicals in biological fluids is a tool to determine the individual exposure. Blood protein adducts of xenobiotics are a null marker of both exposure and the biologically effective dose. Urinary metabolites and blood metabolites are short term exposure markers. Stable hemoglobin adducts are exposure markers of up to 120 days. Blood protein adducts are null formed with many xenobiotics at differen...
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