Can Computational Modeling Predict Disease Phenotype?

Kara Lopez-Lengowski; Annie Kathuria

doi:https://doi.org/10.1016/j.biopsych.2020.04.015

doi.org/10.1016/j.biopsych.2020.04.015

Can Computational Modeling Predict Disease Phenotype?

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Biological Psychiatry10.60

Volume: 88, Issue: 2, Pages: 132 - 133

Published: Jul 1, 2020

Abstract

SEE CORRESPONDING ARTICLES ON PAGES 139 AND 150 Mechanisms Underlying the Hyperexcitability of CA3 and Dentate Gyrus Hippocampal Neurons Derived From Patients With Bipolar DisorderBiological PsychiatryVol. 88Issue 2PreviewApproximately 1 in every 50 to 100 people is affected with bipolar disorder (BD), making this disease a major economic burden. The introduction of induced pluripotent stem cell methodology enabled better modeling of this...