Male reproductive aging arises via multifaceted mating-dependent sperm and seminal proteome declines, but is postponable in Drosophila

Significance Reduced fertility with advancing age is well known in females but understudied in males. Most previous work on male reproductive aging has focused on age-related effects on sperm. However, nonsperm seminal fluid is also vital for fertility but might age differently. Using fruit flies, we find that seminal fluid and sperm are both qualitatively and quantitatively affected by age with each making distinct contributions to declining...