Review paper
Stop testing for autoantibodies to the VGKC-complex: only request LGI1 and CASPR2
Abstract
Autoantibodies to leucine-rich glioma-inactivated 1 (LGI1) and contactin-associated protein like-2 (CASPR2) are associated with clinically distinctive syndromes that are highly immunotherapy responsive, such as limbic encephalitis, faciobrachial dystonic seizures, Morvan’s syndrome and neuromyotonia. These autoantibodies target surface-exposed domains of LGI1 or CASPR2, and appear to be directly pathogenic. In contrast, voltage-gated potassium...
Paper Details
Title
Stop testing for autoantibodies to the VGKC-complex: only request LGI1 and CASPR2
Published Date
Jun 28, 2020
Journal
Volume
20
Issue
5
Pages
377 - 384
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Notes
History