Practical Neurology
Papers 1596
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#1James B. Rowe (University of Cambridge)H-Index: 78
#2Negin Holland (University of Cambridge)H-Index: 5
Last. Timothy Rittman (University of Cambridge)H-Index: 22
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Treating patients with progressive supranuclear palsy (PSP) is both effective and rewarding. This review aims to share our experience in the proactive management of PSP, considering the patient, the family and the medical context in which the illness unfolds. There are many opportunities to assist your patients, ameliorate their symptoms, reduce their risks and harm, and guide them through the complex medical, social and legal minefield that characterises life with chronic neurological illness. ...
#1Jeremy C. S. Johnson (UCL: University College London)H-Index: 3
#2Laura McWhirter (Edin.: University of Edinburgh)H-Index: 8
Last. Rimona S. Weil (UCL: University College London)H-Index: 19
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The early and accurate diagnosis of dementia is more important than ever before but remains challenging. Dementia is increasingly the business of neurologists and, with ageing populations worldwide, will become even more so in future. Here we outline a practical, symptom-led, bedside approach to suspecting dementia and its likely diagnosis, inspired by clinical experience and based on recognition of characteristic syndromic patterns. We show how clinical intuition reflects underlying signature p...
We report the benign clinical course of a ‘hand knob’ stroke syndrome in a 106-year-old man and discuss some issues that arise when caring for the very oldest of the old.
#1Christopher Hutchcroft (University of Salford)
#2Matthew Jones (University of Salford)H-Index: 27
Last. Rajiv Mohanraj (University of Salford)H-Index: 14
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The Last Act of Love , Cathy Rentzenbrink’s account of her brother Matty’s traumatic brain injury and consequent permanent vegetative state, was the first non-fiction book read by our neurology book club. This acclaimed memoir charts the family’s 8-year journey, starting with the initial shock of Matty’s accident and hopes for recovery, through a growing acceptance of his irreversible neurological impairment, and his eventual death following withdrawal of clinically assisted nutrition and hydrat...
#1Clare L. Fraser (USYD: University of Sydney)H-Index: 20
#2Christian J. Lueck (Canberra Hospital)H-Index: 22
First described in 1991 and introduced into clinical practice in 1996, optical coherence tomography (OCT) now has a very extensive role in many different areas of ophthalmological practice. It is non-invasive, cheap, highly reproducible, widely available and easy to perform. OCT also has a role in managing patients with neurological disorders, particularly idiopathic intracranial hypertension. This review provides an overview of the technology underlying OCT and the information it can provide th...
#1Alexander Grundmann (RVI: Royal Victoria Infirmary)
#2Marc Hardwick (University Hospital Southampton NHS Foundation Trust)
Last. James Miller (RVI: Royal Victoria Infirmary)H-Index: 14
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A previously independent 64-year-old man presented to his local hospital with new-onset diplopia and dysarthria while watching television. Over the following days, he developed painless perioral and upper limb sensory disturbance, gait unsteadiness and limb ataxia, most pronounced in the upper limbs. He was initially admitted and treated for a cerebrovascular event, followed by a period of failed rehabilitation. At 6-week review, his symptoms had worsened, and he required the assistance of two p...
#1Fabiano Abrantes (UNIFESP: Federal University of São Paulo)H-Index: 4
#2José Luiz Pedroso (UNIFESP: Federal University of São Paulo)H-Index: 20
Last. Danilo Manuel Cerqueira Costa (UNIFESP: Federal University of São Paulo)H-Index: 2
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A 45-year-old man presented with nausea and new-onset headache. He had a history of congenital obstructive hydrocephalus due to Chiari II malformation, treated during infancy with a ventriculoperitoneal shunt. CT scan of head confirmed ventricular enlargement from shunt failure. Following shunt replacement, his symptoms resolved. MR scan of brain after the procedure showed that the ventricles had reduced in size, but there was an extensive callosal lesion, without diffusion restriction or contra...
#1Maja Christensen (Royal Hobart Hospital)
#2Mathew Wallis (Hobart Corporation)
Last. D. L. Jones (Royal Hobart Hospital)H-Index: 8
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A 20-year-old man presented with recurrent subdural haemorrhages on a background of progressive sensorineural hearing loss, juvenile idiopathic arthritis and intracranial hypertension of unknown cause. His mother had a similar previous history. They both had a persistently mildly elevated serum C reactive protein. Repeat lumbar punctures identified persistently elevated intracranial pressure and mild pleocytosis. A dural biopsy showed necrotising pachymeningitis with granulomatous vasculitis. Th...
#1Christopher E Uy (University of Oxford)
#2Sophie Binks (University of Oxford)H-Index: 4
Last. Sarosh R. Irani (University of Oxford)H-Index: 48
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Autoimmune encephalitis defines brain inflammation caused by a misdirected immune response against self-antigens expressed in the central nervous system. It comprises a heterogeneous group of disorders that are at least as common as infectious causes of encephalitis. The rapid and ongoing expansion of this field has been driven by the identification of several pathogenic autoantibodies that cause polysymptomatic neurological and neuropsychiatric diseases. These conditions often show highly disti...
#1Giorgio LambruH-Index: 10
Last. Manjit Matharu (UCL Institute of Neurology)H-Index: 38
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Trigeminal neuralgia (TN) is a highly disabling disorder characterised by very severe, brief and electric shock like recurrent episodes of facial pain. New diagnostic criteria, which subclassify TN on the basis of presence of trigeminal neurovascular conflict or an underlying neurological disorder, should be used as they allow better characterisation of patients and help in decision-making regarding medical and surgical treatments. MR, including high-resolution trigeminal sequences, should be pe...
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