Electron Transport Chain Complex II Regulates Steroid Metabolism
Abstract
The first steroidogenic enzyme, cytochrome P450-side-chain-cleavage (SCC), requires electron transport chain (ETC) complexes III and IV to initiate steroid metabolic processes for mammalian survival. ETC complex II, containing succinate dehydrogenase (quinone), acts with the TCA cycle and has no proton pumping capacity. We show that complex II is required for SCC activation through the proton pump, generating an intermediate state for addition...
Paper Details
Title
Electron Transport Chain Complex II Regulates Steroid Metabolism
Published Date
Jul 1, 2020
Journal
Volume
23
Issue
7
Pages
101295 - 101295
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