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#1Hua-an Tseng (BU: Boston University)H-Index: 11
#2J. Sherman (BU: Boston University)
Last. Xue Han (BU: Boston University)H-Index: 26
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Summary null null Ultrasound modulates brain activity. However, it remains unclear how ultrasound affects individual neurons in the brain, where neural circuit architecture is intact and different brain regions exhibit distinct tissue properties. Using a high-resolution calcium imaging technique, we characterized the effect of ultrasound stimulation on thousands of individual neurons in the hippocampus and the motor cortex of awake mice. We found that brief 100 millisecond long ultrasound pulses...
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#1Stefano Cestellos-Blanco (University of California, Berkeley)H-Index: 8
Last. Peidong YangH-Index: 187
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SUMMARY null null The conversion of CO2 to value-added products powered with solar energy is an ideal solution to establishing a closed carbon cycle. Combining microorganisms with light-harvesting nanomaterials into photosynthetic biohybrid systems (PBS) presents an approach to reaching this solution. Metabolic pathways precisely evolved for CO2 fixation selectively and reliably generate products. Nanomaterials harvest solar light and biocompatibly associate with microorganisms owing to similar ...
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#1Jordy Evan Sulaiman (HKUST: Hong Kong University of Science and Technology)H-Index: 4
#2Lexin Long (HKUST: Hong Kong University of Science and Technology)
Last. Henry H N Lam (HKUST: Hong Kong University of Science and Technology)H-Index: 30
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Summary null null Recent discoveries indicate that tolerance and resistance could rapidly evolve in bacterial populations under intermittent antibiotic treatment. In the present study, we applied antibiotic combinations in laboratory experiments to generate novel methicillin-resistant Staphylococcus aureus strains with distinct phenotypes (tolerance, resistance, and suppressed tolerance), and compared their proteome profiles to uncover the adaptation mechanisms. While the tolerant strains have v...
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#1Xiaohuan Wang (CAS: Chinese Academy of Sciences)H-Index: 2
#2Long Li (CAS: Chinese Academy of Sciences)H-Index: 5
Last. Fan Song (CAS: Chinese Academy of Sciences)H-Index: 15
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SUMMARY null null The Laplace pressure is one of the most fundamental regulators that determine cell shape and function, and thus has been receiving widespread attention. Here, we systemically investigate the effect of the Laplace pressure on the shape and function of the cells during cytokinesis. We find that the Laplace pressure during cytokinesis can directly control the distribution and size of cell blebbing, and adjust the symmetry of cell division by virtue of changing the characteristics ...
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#1Tomoya Sasahara (Kyoto University)H-Index: 3
#2Kaori Satomura (Kyoto University)H-Index: 5
Last. Minako Hoshi (Kyoto University)H-Index: 13
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Summary null null Amyloid β-protein (Aβ) may contribute to worsening of Alzheimer's disease (AD) through vascular dysfunction, but the molecular mechanism involved is unknown. Using ex-vivo blood vessels and primary endothelial cells from human brain microvessels, we show that patient-derived Aβ assemblies, termed amylospheroids (ASPD), exist on the microvascular surface in patients’ brains and inhibit vasorelaxation through binding to the α3 subunit of sodium, potassium-ATPase (NAKα3) in caveol...
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#1Molly Phillips (UCM: University of California, Merced)H-Index: 2
#2Alauna Wheeler (UCM: University of California, Merced)
Last. Chris T. Amemiya (UCM: University of California, Merced)H-Index: 70
view all 8 authors...
Summary null null Cartilaginous fishes possess gel-filled tubular sensory organs called Ampullae of Lorenzini (AoL) that are used to detect electric fields. Although recent studies have identified various components of AoL gel, it has remained unclear how the molecules are structurally arranged and how their structure influences the function of the organs. Here we describe the structure of AoL gel using microscopy and small angle x-ray scattering, and infer that the material is colloidal in natu...
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#1Jason J. Gokey (VUMC: Vanderbilt University Medical Center)H-Index: 1
#2John Snowball (Cincinnati Children's Hospital Medical Center)H-Index: 7
Last. Jeffrey A. Whitsett (University of Cincinnati Academic Health Center)H-Index: 93
view all 7 authors...
Summary null null Ventilation is dependent upon pulmonary alveoli lined by two major epithelial cell types, alveolar type-1 (AT1) and 2 (AT2) cells. AT1 cells mediate gas exchange while AT2 cells synthesize and secrete pulmonary surfactants and serve as progenitor cells which repair the alveoli. We developed transgenic mice in which YAP was activated or deleted to determine its roles in alveolar epithelial cell differentiation. Postnatal YAP activation increased epithelial cell proliferation, in...
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#1Haoyu RuanH-Index: 3
Last. Kun ChenH-Index: 2
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#1Anna Hojka-Osinska (International Institute of Minnesota)H-Index: 5
#2Aleksander Chlebowski (PAN: Polish Academy of Sciences)H-Index: 2
Last. Andrzej Dziembowski (International Institute of Minnesota)H-Index: 38
view all 0 authors...
SUMMARY null null Processive exoribonucleases are executors of RNA decay. In humans, their physical but not functional interactions were thoughtfully investigated. Here we have screened cells deficient in DIS3, XRN2, EXOSC10, DIS3L, and DIS3L2 with a custom siRNA library and determined their genetic interactions with diverse pathways of RNA metabolism. We uncovered a complex network of positive interactions that buffer alterations in RNA degradation and reveal reciprocal cooperation with genes i...
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#1Bhaskar Jyoti Borah (NTU: National Taiwan University)
#2Jye-Chang Lee (NTU: National Taiwan University)H-Index: 1
Last. Chi-Kuang Sun (NTU: National Taiwan University)H-Index: 52
view all 0 authors...
Summary null null The Nyquist-Shannon criterion has never been realized in a laser-scanning mesoscopic multiphoton microscope (MPM) with a large field-of-view (FOV)-resolution ratio, especially when employing a high-frequency resonant-raster-scanning. With a high optical resolution nature, a current mesoscopic-MPM either neglects the criterion and degrades the digital resolution to twice the pixel size, or reduces the FOV and/or the raster-scanning speed to avoid aliasing. We introduce a Nyquist...
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