Vitamin-B12-Conjugated Sericin Micelles for Targeting Gastric Cancer and Reversing Drug Resistance

Although paclitaxel (PTX) is a promising front-line agent for gastric cancer (GC), its hydrophobic characteristics and ineffective cancer site access have limited its clinical applications. Previously, we have introduced nanosized drug delivery systems based on sericin micelles, to reverse drug resistance. However, these micelles lacked the ability to selectively bind and directly affect cancer cells. In general, vitamin B12 (VB12) is highly...