Jiang Yu
Southern Medical University
CancerInternal medicineRadiologySurgeryOncologyRetrospective cohort studyRandomized controlled trialStage (cooking)ChemistryLaparoscopic surgeryChemotherapyMetastasisLaparoscopyGastrectomyLymph nodeNomogramCancer researchColorectal cancerGeneral surgeryMedicineCohortBiologyGastroenterology
175Publications
27H-index
2,556Citations
Publications 175
Newest
BACKGROUND The tumour stroma microenvironment plays an important part in disease progression and its composition can influence treatment response and outcomes. Histological evaluation of tumour stroma is limited by access to tissue, spatial heterogeneity, and temporal evolution. We aimed to develop a radiological signature for non-invasive assessment of tumour stroma and treatment outcomes. METHODS In this multicentre, retrospective study, we analysed CT images and outcome data of 2209 patients ...
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#1Zhanke He (Southern Medical University)H-Index: 1
#2Da Chen (Southern Medical University)H-Index: 2
Last. Xingxing Yao (Southern Medical University)H-Index: 4
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Abstract The antimetabolite 5-fluorouracil (5-FU) is a widely used chemotherapy regimen for the treatment of gastric cancer (GC). However, resistance to 5-FU remains a major drawback in the clinical use. The treatments of anti-tumor chemo-agents recruit tumor associated macrophages (TAMs) which are highly implicated in the chemoresistance development, but the underlying molecular mechanism is unclear. Here, we demonstrate that YAP1 is overexpressed in resistant GC tissues compared to sensitive G...
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#1Xing Huang (Southern Medical University)
#2Hao Liu (Southern Medical University)H-Index: 22
Last. Guoxin Li (Southern Medical University)H-Index: 33
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BACKGROUND The prognosis of stage III gastric cancer (GC) patients based on the 8th edition TNM staging system after D2 dissection was still heterogeneous. We aimed to explore clinicopathological reasons that led to the poor prognosis of these patients, especially from a surgical aspect. METHODS We divided 320 stage III GC patients who underwent distal or total gastrectomy with D2 lymphadenectomy into group 1 and group 2, according to the disease-free survival (DFS), and compared the clinicopath...
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#1Chen Xinhua (Southern Medical University)H-Index: 4
Last. Jiang Yu (Southern Medical University)H-Index: 27
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Background Gastric linitis plastica (GLP) is characteristic by its poor prognosis and highly aggressive characteristics compared with other types of gastric cancer (GC). However, the guidelines have not yet been distinguished between GLP and non-GLP. Methods A total of 342 eligible patients with GLP identified in the Surveillance, Epidemiology, and End Results (SEER) dataset were randomly divided into training set (n=298) and validation set (n=153). A nomogram would be developed with the constru...
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#1Yanrui Liang (Southern Medical University)H-Index: 2
#2Liying Zhao (Southern Medical University)H-Index: 17
Last. Guoxin Li (Southern Medical University)H-Index: 33
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BACKGROUND The benefits of adjuvant chemotherapy for elderly patients with gastric cancer (GC) remain unknown because elderly patients are underrepresented in most clinical trials. This study aimed to evaluate the effectiveness and complications of adjuvant chemotherapy in patients > 65 years of age after laparoscopic D2 gastrectomy. METHODS This was a single-center retrospective cohort study of elderly patients (> 65 years) with stage II/III GC who underwent curative laparoscopic D2 gastrectomy...
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#1Mansheng Zhu (Southern Medical University)
#2Qixiang Liang (SYSU: Sun Yat-sen University)
Last. Guoxin Li (Southern Medical University)H-Index: 33
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BACKGROUND The recent discovery of cancer/tissue specificity of miRNA has indicated its great potential as a therapeutic target. In Epstein-Barr virus-associated gastric cancer (EBVaGC), host genes are affected by extensive DNA methylation, including miRNAs. However, the role of methylated miRNA in the development of EBVaGC and immune cell infiltration has largely remained elusive. RESULTS After crossmatching the DNA methylation and expression profile of miRNA and mRNA in the Gene Expression Omn...
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#1Yuming Jiang (Stanford University)H-Index: 15
#2Xiaokun Liang (CAS: Chinese Academy of Sciences)H-Index: 7
Last. Yaoqin Xie (CAS: Chinese Academy of Sciences)H-Index: 24
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Importance Occult peritoneal metastasis frequently occurs in patients with advanced gastric cancer and is poorly diagnosed with currently available tools. Because the presence of peritoneal metastasis precludes the possibility of curative surgery, there is an unmet need for a noninvasive approach to reliably identify patients with occult peritoneal metastasis. Objective To assess the use of a deep learning model for predicting occult peritoneal metastasis based on preoperative computed tomograph...
3 CitationsSource
#1Chen Xinhua (Southern Medical University)H-Index: 4
#2Yu Zhu (Southern Medical University)H-Index: 4
Last. Guoxin Li (Southern Medical University)H-Index: 33
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Background: The enhanced recovery after surgery (ERAS) programme is feasible and effective in reducing the length of hospital stay, overall complication rates and medical costs when applied to cases involving colonic and rectal resections. However, a recent prospective, randomised, open, parallel-controlled trial (Chinese Laparoscopic Gastrointestinal Surgery Study-01 trial), initiated by our team, indicated that under conventional peri-operative management, the reduction of the post-operative h...
1 CitationsSource
#1Zhian Chen (Southern Medical University)H-Index: 2
#2Yanrui Liang (Southern Medical University)H-Index: 2
Last. Yanfeng Hu (Southern Medical University)H-Index: 22
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Among various methods, the use of targeting nucleic acid therapy is a promising method for inhibiting gastric cancer (GC) cells' rapid growth and metastasis abilities. In this study, vitamin B12-labeled poly (d,l-lactide-co-glycolide) and polyethylene glycol nanoparticles (PLGA-PEG-VB12 NPs) were developed for microRNAs-532-3p mimics incorporating as targeting gene delivery systems (miR-532-3p@PLGA-PEG-VB12 NPs) to fight against transcobalamin II (CD320)-overexpressed GC cells' progression. The ...
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