Yanfeng Hu
Southern Medical University
CancerInternal medicineRadiologySurgeryOncologyLogistic regressionRetrospective cohort studyRandomized controlled trialStage (cooking)ChemistryLaparoscopic surgeryChemotherapyMetastasisLaparoscopyGastrectomyLymph nodeNomogramCancer researchProportional hazards modelMedicine
130Publications
22H-index
1,938Citations
Publications 127
Newest
#1Xing Huang (Southern Medical University)
#2Hao Liu (Southern Medical University)H-Index: 22
Last. Guoxin Li (Southern Medical University)H-Index: 33
view all 6 authors...
BACKGROUND The prognosis of stage III gastric cancer (GC) patients based on the 8th edition TNM staging system after D2 dissection was still heterogeneous. We aimed to explore clinicopathological reasons that led to the poor prognosis of these patients, especially from a surgical aspect. METHODS We divided 320 stage III GC patients who underwent distal or total gastrectomy with D2 lymphadenectomy into group 1 and group 2, according to the disease-free survival (DFS), and compared the clinicopath...
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#1Yanrui Liang (Southern Medical University)H-Index: 2
#2Liying Zhao (Southern Medical University)H-Index: 17
Last. Guoxin Li (Southern Medical University)H-Index: 33
view all 10 authors...
BACKGROUND The benefits of adjuvant chemotherapy for elderly patients with gastric cancer (GC) remain unknown because elderly patients are underrepresented in most clinical trials. This study aimed to evaluate the effectiveness and complications of adjuvant chemotherapy in patients > 65 years of age after laparoscopic D2 gastrectomy. METHODS This was a single-center retrospective cohort study of elderly patients (> 65 years) with stage II/III GC who underwent curative laparoscopic D2 gastrectomy...
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#1Weihong Guo (Southern Medical University)H-Index: 6
#2Zhian Chen (Southern Medical University)H-Index: 2
Last. Yanfeng Hu (Southern Medical University)H-Index: 22
view all 9 authors...
Background Paclitaxel (PTX) has been suggested to be a promising front-line drug for gastric cancer (GC), while P-glycoprotein (P-gp) could lead to drug resistance by pumping PTX out of GC cells. Consequently, it might be a hopeful way to combat drug resistance by inhibiting the out-pumping function of P-gp. Results In this study, we developed a drug delivery system incorporating PTX onto polyethylene glycol (PEG)-modified and oxidized sodium alginate (OSA)-functionalized graphene oxide (GO) nan...
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#1Yuming Jiang (Stanford University)H-Index: 15
#2He Wang (Stanford University)H-Index: 58
Last. Ruijiang Li (Stanford University)H-Index: 32
view all 13 authors...
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#1Mansheng Zhu (Southern Medical University)
#2Qixiang Liang (SYSU: Sun Yat-sen University)
Last. Guoxin Li (Southern Medical University)H-Index: 33
view all 12 authors...
BACKGROUND The recent discovery of cancer/tissue specificity of miRNA has indicated its great potential as a therapeutic target. In Epstein-Barr virus-associated gastric cancer (EBVaGC), host genes are affected by extensive DNA methylation, including miRNAs. However, the role of methylated miRNA in the development of EBVaGC and immune cell infiltration has largely remained elusive. RESULTS After crossmatching the DNA methylation and expression profile of miRNA and mRNA in the Gene Expression Omn...
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#1Chen Xinhua (Southern Medical University)H-Index: 4
#2Yu Zhu (Southern Medical University)H-Index: 4
Last. Guoxin Li (Southern Medical University)H-Index: 33
view all 11 authors...
Background: The enhanced recovery after surgery (ERAS) programme is feasible and effective in reducing the length of hospital stay, overall complication rates and medical costs when applied to cases involving colonic and rectal resections. However, a recent prospective, randomised, open, parallel-controlled trial (Chinese Laparoscopic Gastrointestinal Surgery Study-01 trial), initiated by our team, indicated that under conventional peri-operative management, the reduction of the post-operative h...
1 CitationsSource
#1Zhian Chen (Southern Medical University)H-Index: 2
#2Yanrui Liang (Southern Medical University)H-Index: 2
Last. Yanfeng Hu (Southern Medical University)H-Index: 22
view all 16 authors...
Among various methods, the use of targeting nucleic acid therapy is a promising method for inhibiting gastric cancer (GC) cells' rapid growth and metastasis abilities. In this study, vitamin B12-labeled poly (d,l-lactide-co-glycolide) and polyethylene glycol nanoparticles (PLGA-PEG-VB12 NPs) were developed for microRNAs-532-3p mimics incorporating as targeting gene delivery systems (miR-532-3p@PLGA-PEG-VB12 NPs) to fight against transcobalamin II (CD320)-overexpressed GC cells' progression. The ...
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#1Chang-Ming HuangH-Index: 2
#1Changming HuangH-Index: 1
Last. Guoxin Li (Southern Medical University)H-Index: 33
view all 23 authors...
BACKGROUND: It is not clear whether laparoscopic and open distal gastrectomy produce similar outcomes in patients with locally advanced gastric cancer. Data from a multicenter, randomized, controlled trial (CLASS-01) showed that laparoscopic distal gastrectomy did not result in inferior disease-free survival at 3 years compared with open distal gastrectomy. Here, we present 5-year overall survival data from this trial. METHODS: From September 2012 through December 2014, we randomly assigned 1056...
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#1Chen XinhuaH-Index: 4
#3Chen YuehongH-Index: 3
Last. Jiang YuH-Index: 27
view all 12 authors...
Objective This study aimed to determine the impact of type 2 diabetes mellitus (T2DM) on clinical outcomes of gastric cancer (GC) patients and explore whether metformin use and good glycemic control could reverse it. Methods Clinicopathologic data of consecutive GC patients who underwent gastrectomy at Nanfang Hospital between October 2004 and December 2015 were included. Propensity score matching (PSM) was performed to balance the important factors of the disease status between non-T2DM and T2D...
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INTRODUCTION Treatments for young patients with gastric cancer (GC) remain poorly defined, and their effects on survival are uncertain. We aimed to investigate the receipt of chemotherapy by age category (18-49, 50-64, and 65-85 years) and explore whether age differences in chemotherapy matched survival gains in patients with GC. METHODS Patients who were histologically diagnosed with GC were included from a Chinese multi-institutional database and the Surveillance, Epidemiology, and End Results...
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