Original paper
Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer
Abstract
Tumor cells rely on glutamine to fulfill their metabolic demands and sustain proliferation. The elevated consumption of glutamine can lead to intratumoral nutrient depletion, causing metabolic stress that has the potential to impact tumor progression. Here, we show that nutrient stress caused by glutamine deprivation leads to the induction of epithelial-mesenchymal transition (EMT) in pancreatic ductal adenocarcinoma (PDAC) cells....
Paper Details
Title
Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer
Published Date
Jun 8, 2020
Volume
217
Issue
9
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