High-Dose Vitamin D Does Not Prevent Postoperative Recurrence of Crohn’s Disease in a Randomized Placebo-Controlled Trial

Background & AimsVitamin D deficiency is common in Crohn’s disease (CD). High-dose vitamin D had anti-inflammatory effects in preclinical studies and trials of patients with CD. We performed a randomized trial to determine whether high-dose vitamin D prevents postoperative recurrence of CD after ileocolonic resection.MethodsPatients with CD after ileocolonic resection with ileocolonic anastomosis were assigned randomly to groups given weekly...