Background & Aims Hepatocellular carcinoma (HCC) can be treated effectively if detected at an early stage. Recommended surveillance strategies for at-risk patients include ultrasound with or without α-fetoprotein (AFP), but their sensitivity is suboptimal. We sought to develop a novel, blood-based biomarker panel with improved sensitivity for early-stage HCC detection. Methods In a multicenter, case-control study, we collected blood specimens from patients with HCC and age-matched controls with ...
#1Wei Jiang(CUHK: Chinese University of Hong Kong)
#2Bing Yee Suen(CUHK: Chinese University of Hong Kong)H-Index: 8
Last. Joyce Wing Yan Mak(CUHK: Chinese University of Hong Kong)H-Index: 8
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Abstract Background Although there are international guidelines on the management of anti-thrombotic therapy in patients undergoing colonoscopic polypectomy, whether clinicians and patients follow these recommendations are largely unknown. Aims We aimed to evaluate clinicians’ adherence and patients’ compliance to peri-endoscopic management of antithrombotic therapy and their impact on clinical outcomes. Methods Consecutive patients on anti-thrombotic therapy scheduled for elective colonoscopy i...
Background The IBD disability index (IBDDI) has been shown to be valid and reliable. We compared the distributional and predictive properties of the IBDDI, when collected from five populations of people living with IBD– from Winnipeg, Chicago, Toronto, Hong Kong, and Jerusalem. Methods People with IBD from five jurisdictions were invited to complete a survey including the IBDDI, the World Health Organization Disability Assessment Scale, the Work and Social Adjustment Scale, the IBDQ, the Kessler...
#1Giorgos Bamias(National and Kapodistrian University of Athens)H-Index: 35
#2Fabio Cominelli(CWRU: Case Western Reserve University)H-Index: 63
The development of Crohn's disease (CD) is characterized by a breakdown of homeostatic immune-bacterial communication, which takes place at the intestinal mucosa when environmental triggers impact genetically predisposed individuals. Converging lines of evidence support the hypothesis that this pathogenetic model develops through sequential, although inter-related, steps that indicate failure of mucosal defense mechanisms at various stages. In this context, immunologic phenomena that mediate the...
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