Coronavirus

2019-20 coronavirus outbreak

Betacoronavirus

Viral therapy

Virology

China

Medical physics

Computer science

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Outbreak

Radiation therapy

Environmental health

Coronavirus disease 2019 (COVID-19)

Radiology

Discontinuation

Political science

Family medicine

Infectious disease (medical specialty)

Internal medicine

Coronavirus Infections

Medicine

Pandemic

Disease

Radiotherapy and Oncology

Following the announcement of the COVID-19 pandemic by the World Health Organization in March 2020, the outbreak of new coronavirus in Iran and most of the world has posed severe challenges in the treatment of cancer patients. This group of patients is more prone to this new virus due to immune-compromised status following active treatment and frequent visits to hospitals [[1]Liang W. Guan W. Chen R. Wang W. Li J. Xu K. et al.Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China [Internet].Lancet Oncol. 2020; 21 ([cited 2020 Mar 29]. p. 335–7. Available from: https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(20)30096-6/fulltext?utm_source=yxnews&utm_medium=desktop&utm_referrer=https%3A%2F%2Fyandex.com%2Fnews)Abstract Full Text Full Text PDF Scopus (3238) Google Scholar]. At the onset of the outbreak, discontinuation, or postponing, the nonemergent treatments were considered. In contrary to this idea, as time goes on, we understand that this problem is not a short duration crisis. It is not logical to deprive patients of life-saving treatment like radiotherapy (RT). As we all know, delaying RT in some patients will lead to reducing the benefit of this treatment and affected patient survival, as well as, it can cause a high mortality rate for patients and also a higher financial burden on health systems after the COVID 19 era. Therefore canceling or too much delay in available treatment options does not seem to be logical. In this regard, in Iran Cancer Institute, we have reached a consensus based on the evidence available in the literature, and according to the available facilities. The main problem was how to continue the activity while protecting patients, families, and health professionals from the infection. Some measures by a working group can help deliver safe radiotherapy [2Slotman B, Ricardi U, Lievens Y. Radiotherapy in a time of crisis, ESTRO Presidents's' statement [Internet]. [cited 2020 Mar 25]. Available from: https://www.estro.org/About/Newsroom/News/Radiotherapy-in-a-time-of-crisis.Google Scholar, 3NHS. Specialty guides for patient management during the coronavirus pandemic: clinical guide for the management of noncoronavirus patients requiring acute treatment: Cancer [Internet]. [cited 2020 Mar 29]. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/869827/Coro.Google Scholar]:•To educate staff to triage suspicious patients,•To provide maximum protective care for health care workers contact to patients,•To encourage patients to protect themselves by personal protective equipment, physical distancing and•To separate highly vulnerable patients (e.g., patients >65-years with severe comorbidities) in the early day and terminal cleaning of treatment rooms and clinics according to local guidelines. For early detection of positive cases of COVID-19, in our center, an online system has been set up to register patients' symptoms and their underlying disorders like cancer, in case of any suspicion of COVID-19; they will be contacted in order to get treatment and supportive care as soon as possible.•In COVID-19 confirmed infected patients, we do not start radiotherapy, and discontinue the treatment that began before, till the patient becomes symptom-free for 14 days or two negative PCR tests. Therefore in some circumstances like cord compression, radiotherapy is crucial for the patient. We recommend doing the radiotherapy at the end of the shift to limit the chance of exposure, and after the treatment, all the facilities should be sanitized.•If there is any suspicion of COVID-19 infection in the presence of typical symptoms during radiotherapy, the treatment should be paused until the confirmatory tests are done. Considering the sensitivity of SARS-cov2 PCR is 43–70% (it depends on where the sample took place) in our hospital, even if the PCR is negative for COVID-19, we withhold the radiotherapy for at least two weeks. Coping with the pandemic, we made a priority list of the indications for radiation therapy (Table 1) based on other published guidelines [3NHS. Specialty guides for patient management during the coronavirus pandemic: clinical guide for the management of noncoronavirus patients requiring acute treatment: Cancer [Internet]. [cited 2020 Mar 29]. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/869827/Coro.Google Scholar, 4Riccardo Filippi A. Russi E. Maria Magrini S. Corvò R. COVID-19 outbreak in nothern Italy: first practical indications for radiotherapy drpartments [in press].Int J Radiat Oncol Biol Phys [Internet]. 2020; ([cited 2020 Mar 29]; Available from: https://doi.org/10.1016/j.ijrobp.2020.03.007)Google Scholar, 5Simcock R. Thomas T. Mercy C. AF-C and, 2020 undefined. COVID-19: global radiatio oncology's's targeted response for pandemic preparedness. Elsevier [Internet], 2020Google Scholar] and the available evidence on the cost of treatment delays [[6]Neal R, Tharmanathan P, France B, ND-B journal of, 2015 undefined. Is increased time to diagnosis and treatment in symptomatic cancer associated with poorer outcomes? Systematic review. nature.com [Internet]. [cited 2020 Mar 29]; Available from: https://www.nature.com/articles/bjc201548/.Google Scholar]. However, as time passed, we decided to emphasize more on the modification of treatment rather than postponing. In case of a modification of RT treatment, generally, hypofractionated regimens are preferred over conventional, albeit with established evidence. For example, in rectal cancer, we could opt for short-course radiotherapy with immediate or delayed surgery [[7]Aghili M. Sotoudeh S. Ghalehtaki R. Babaei M. Farazmand B. Fazeli M.S. et al.Preoperative short course radiotherapy with concurrent and consolidation chemotherapies followed by delayed surgery in locally advanced rectal cancer: preliminary results.Radiat Oncol J. 2018; 36: 17-24Crossref PubMed Scopus (18) Google Scholar]. Another good examples are the hypofractionated whole-breast irradiation [[8]Smith B.D. Bellon J.R. Blitzblau R. Freedman G. Haffty B. Hahn C. et al.Radiation therapy for the whole breast: executive summary of an American Society for Radiation Oncology (ASTRO) evidence-based guideline.Pract Radiat Oncol. 2018; 8: 145-152Abstract Full Text Full Text PDF PubMed Scopus (415) Google Scholar] or accelerated partial breast irradiation for eligible candidates. For prostate cancers that radiation of the whole pelvis is not intended, we can use stereotactic body radiation therapy (SBRT), an abbreviated course, or a single 19-Gy-fraction of high-dose-rate (HDR) brachytherapy [9Freedman-Cass D. Shead D.A. Armstrong A.J. Bekelman J.E. Cheng H. Victor A.D. et al.Guidelines panel disclosures NCCN guidelines version 1.2020.Prostate Cancer. 2020; Google Scholar, 10Siddiqui Z.A. Gustafson G.S. Ye H. Martinez A.A. Mitchell B. Sebastian E. et al.Five-year outcomes of a single-institution prospective trial of 19-Gy single-fraction high-dose-rate brachytherapy for low- and intermediate-risk prostate cancer.Int J Radiat Oncol Biol Phys. 2019; 104: 1038-1044Abstract Full Text Full Text PDF PubMed Scopus (46) Google Scholar]. In cases in which we are desperate to use a conventional schedule, we could opt for techniques with less time-consuming fractions to minimize patients' exposure and staff work-load at all possible. For example, when there is minimal difference between 3D conformal RT and IMRT, we prefer 3D. For palliative radiation, a single 8-Gy-fraction or four 5-Gy-fractions for bone and brain metastasis, respectively, are encouraged. In the case of concurrent chemo-radiotherapy, we know that in all scenarios, it may increase the complications of treatment. Thus, each treating physician should weigh the benefits over the risk of toxicities, primarily bone marrow suppression. Administration of chemotherapy orally, or in the outpatient setting or at home, is proposed to reduce visits. It may be reasonable to postpone regular follow-up visits of patients not on active cancer treatment or to conduct those appointments via telemedicine. It is highly recommended to have virtual MDT for decision making in the radiation oncology clinics during the COVID-19 outbreak with the use of social network applications. In the current COVID-19 crisis, the safe delivery of radiation therapy should follow institutional protocols set based on logistics and priorities. The authors declare no conflict of interests. The following are the Supplementary data to this article: Download .docx (.01 MB) Help with docx files Supplementary data 1

Radiotherapy and COVID-19: Practical recommendations from iran