Systemic transsulfuration pathway thiol concentrations in chronic obstructive pulmonary disease patients.

Published on May 7, 2020in European Journal of Clinical Investigation3.481
· DOI :10.1111/ECI.13267
Angelo Zinellu31
Estimated H-index: 31
(University of Sassari),
Elisabetta Zinellu16
Estimated H-index: 16
+ 8 AuthorsPietro Pirina26
Estimated H-index: 26
(University of Sassari)
It is amply reported that patients with chronic obstructive pulmonary disease (COPD) have increased risk of cardiovascular disease (CVD). Recent evidence suggests that COPD patients have elevated concentrations of plasma homocysteine (Hcy), a transsulfuration pathway analyte that is commonly regarded as a CVD risk factor. We comprehensively investigated the plasma concentrations of transsulfuration pathway analytes, and their relationship with markers of oxidative stress and inflammation, to identify which low molecular thiols might play a pathophysiological role both in CVD and in COPD. Hcy, cysteine (Cys), glutathione (GSH), cysteinylglycine (CysGly), glutamylcysteine (GluCys), taurine (Tau), oxidative stress markers (TBARS and protein-SH, PSH) and the inflammation marker Kynurenine/Tryptophan (Kyn/Trp) ratio, were measured in 54 COPD patients and 54 control subjects. We found increased concentrations of total Hcy (p<0.01) and total CysGly (p<0.05) in COPD patients when compared to controls. Total Hcy and CysGly were also significantly associated with abnormal lung function parameters and COPD severity. In COPD patients, Total Hcy was significantly associated with the Kyn/Trp ratio (p=0.0017) whereas total CysGly was significantly associated with both PSH (p=0.0298) and the Kyn/Trp ratio (p=<0.0001). Both total Hcy and CysGly concentrations were significantly associated with the presence and severity of COPD and with markers of oxidative stress (total CysGly) and inflammation (total Hcy and CysGly). This suggests that specific low molecular mass thiols might play a role in the inflammatory and oxidative stress pathways involved in both CVD and COPD.
📖 Papers frequently viewed together
8 Citations
4 Citations
3 Authors (V. Ilieva, ..., Veselina Gadjeva)
1 Citations
#1Deepti Chaudhary (Central University of Punjab)H-Index: 1
#2Nidhi Sharma (Central University of Punjab)H-Index: 1
Last. Sabyasachi Senapati (Central University of Punjab)H-Index: 9
view all 3 authors...
Background: Serum homocysteine (Hcy) level inversely related with concentration of folic acid, which is an essential micronutrient for metabolism and energy homeostasis. Serum concentrations of Hcy have been reported to have strong correlation with smoking, which is a major risk factor for pathogenesis of chronic obstructive pulmonary disease (COPD) irrespective of ethnicity and gender. Therefore we performed a systematic review based meta-analysis to evaluate the overall contribution of Hcy in ...
4 CitationsSource
#1Klaus F. Rabe (CAU: University of Kiel)H-Index: 107
#2John R. Hurst (UCL: University College London)H-Index: 51
Last. Samy Suissa (McGill University)H-Index: 108
view all 3 authors...
Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) frequently occur together and their coexistence is associated with worse outcomes than either condition alone. Pathophysiological links between COPD and CVD include lung hyperinflation, systemic inflammation and COPD exacerbations. COPD treatments may produce beneficial cardiovascular (CV) effects, such as long-acting bronchodilators, which are associated with improvements in arterial stiffness, pulmonary vasoconstrict...
72 CitationsSource
#1Panagiotis Paliogiannis (University of Sassari)H-Index: 19
#2Alessandro G. Fois (University of Sassari)H-Index: 17
Last. Angelo Zinellu (University of Sassari)H-Index: 31
view all 8 authors...
INTRODUCTION:The main white blood cell populations, neutrophils and lymphocytes, are involved in the pathophysiology of chronic obstructive pulmonary disease (COPD). We conducted a systematic review and meta-analysis of studies investigating the relationship between the neutrophil to lymphocyte ratio (NLR, a marker of subclinical inflammation), presence of COPD, and its exacerbations. METHODS:A comprehensive literature search was conducted in Pubmed, Web of Science and Scopus databases; two inve...
12 CitationsSource
#1Panagiotis Paliogiannis (University of Sassari)H-Index: 19
#2Alessandro G. Fois (University of Sassari)H-Index: 17
Last. Angelo Zinellu (University of Sassari)H-Index: 31
view all 8 authors...
: The aim of this meta-analysis was to review the available evidence regarding the blood concentrations of the oxidative stress marker malondialdehyde (MDA) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. 14 studies were included in the meta-analysis (from inception to October 2017) with a total of 817 COPD patients and 530 healthy controls. Pooled MDA concentrations were significantly higher in patients with COPD than controls (standardized mean di...
9 CitationsSource
#1Elisabetta ZinelluH-Index: 16
#2Angelo Zinellu (University of Sassari)H-Index: 31
Last. Pietro PirinaH-Index: 26
view all 5 authors...
Chronic obstructive pulmonary disease (COPD) is a progressive condition characterized by airflow limitation associated with an abnormal inflammatory response of the lungs to noxious particles and gases, caused primarily by cigarette smoking. Increased oxidative burden plays an important role in the pathogenesis of COPD. There is a delicate balance between the toxicity of oxidants and the protective function of the intracellular and extracellular antioxidant defense systems, which is critically i...
65 CitationsSource
#1Angelo Zinellu (University of Sassari)H-Index: 31
#2Alessandro G. Fois (University of Sassari)H-Index: 17
Last. Ciriaco Carru (University of Sassari)H-Index: 38
view all 9 authors...
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
16 CitationsSource
#1Bin Su (Tianjin University of Traditional Chinese Medicine)H-Index: 1
#2Tiansheng LiuH-Index: 1
Last. Shike HouH-Index: 10
view all 8 authors...
Systemic inflammatory factors are inconsistently associated with the pathogenesis of chronic obstructive pulmonary disease (COPD). We conducted a systematic review and meta-analysis to summarize the evidence supporting the association between systemic inflammation and the risk of COPD. Pertinent studies were retrieved from PubMed, EmBase, and the Cochrane Library until April 2015. A random-effects model was used to process the data, and the analysis was further stratified by factors affecting th...
50 CitationsSource
#1Angelo Zinellu (University of Sassari)H-Index: 31
#2Alessandro G. Fois (University of Sassari)H-Index: 17
Last. Pietro Pirina (University of Sassari)H-Index: 26
view all 9 authors...
Chronic obstructive pulmonary disease (COPD) and asthma are both characterized by heterogeneous chronic airway inflammation and obstruction as well as oxidative stress (OS). However, it is unknown whether OS occurs in early disease and how to best assess its presence. Plasma OS markers (TBARS, PSH, taurine, GSH, ergothioneine and paraoxonase 1 activity) and lung function tests were measured in patients with mild stable asthma (n = 24) and mild stable COPD (n = 29) and in age- and sex-matched con...
33 CitationsSource
#1Paul Ganguly (Alfaisal University)H-Index: 6
#2Sreyoshi Fatima Alam (Alfaisal University)H-Index: 3
It is well known that neuronal damage following a stroke has been attributed to the over stimulation of excitatory amino acids such as glutamate and aspartate through activation of NMDA receptors. The brain is exposed to most of the constituents of plasma including homocysteine as a result of the disruption of the blood–brain barrier after stroke, head trauma and stress. The question, therefore, arises as to whether or not homocysteine is able to selectively stimulate the release of excitatory a...
448 CitationsSource
#1Song Zhang (Chinese PLA General Hospital)H-Index: 1
#2Yongyi Bai (Chinese PLA General Hospital)H-Index: 11
Last. Ping Ye (Chinese PLA General Hospital)H-Index: 15
view all 6 authors...
Background Arterial stiffness and homocysteine are both powerful predictors of cardiovascular disease, especially in older populations. Previous studies have investigated the association of homocysteine with arterial stiffness in human subjects, while the relationship between homocysteine and arterial stiffness in the elderly is still indefinite. The current study examined the association of homocysteine with arterial stiffness in Chinese community-based elderly persons. Methods We related serum...
54 CitationsSource
Cited By6
#1Akihiko TaniguchiH-Index: 10
#2Mitsuru TsugeH-Index: 10
Last. Hirokazu TsukaharaH-Index: 39
view all 4 authors...
The respiratory system is continuously exposed to endogenous and exogenous oxidants. Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation of the airways, leading to the destruction of lung parenchyma (emphysema) and declining pulmonary function. It is increasingly obvious that reactive oxygen species (ROS) and reactive nitrogen species (RNS) contribute to the progression and amplification of the inflammatory responses related to this disease. First, we described ...
#1Marta Marszalek-Grabska (Medical University of Lublin)H-Index: 8
#2Katarzyna Walczak (Medical University of Lublin)H-Index: 10
Last. Waldemar A. Turski (Medical University of Lublin)H-Index: 48
view all 7 authors...
Kynurenine (KYN), a main metabolite of tryptophan in mammals, is a direct precursor of kynurenic acid, anthranilic acid and 3-hydroxykynurenine. Under physiological conditions, KYN is produced endogenously mainly in the liver by tryptophan 2,3-dioxygenase (TDO). Tumorigenesis and inflammatory conditions increase the activity of another KYN synthetizing enzyme, indoleamine 2,3-dioxygenase (IDO). However, knowledge about the exogenous sources and the fate of KYN in mammals is still limited. While ...
2 CitationsSource
#1Ankush Sharma (LPU: Lovely Professional University)
#2Devesh Tewari (LPU: Lovely Professional University)H-Index: 18
Last. Solomon Habtemariam (University of Greenwich)H-Index: 44
view all 5 authors...
Abstract Adapted to effectively capture oxygen from inhaled air and deliver it to all other parts of the body, the lungs constitute the organ with the largest surface area. This makes the lungs more susceptible to airborne pathogens and pollutants that mediate pathologies through generation of reactive oxygen species (ROS). One pathological consequence of excessive levels of ROS production is pulmonary diseases that account for a large number of mortality and morbidity in the world. Of the vario...
#1Salvatore SotgiaH-Index: 25
#2Alessandro G. FoisH-Index: 17
Last. Angelo ZinelluH-Index: 31
view all 6 authors...
This study aimed to review and critically appraise the current methodological issues undermining the suitability of the measurement of serum/plasma glutathione, both in the total and reduced form, as a measure of systemic oxidative stress in chronic obstructive pulmonary disease (COPD). Fourteen relevant articles published between 2001 and 2020, in 2003 subjects, 1111 COPD patients, and 892 controls, were reviewed. Nine studies, in 902 COPD patients and 660 controls, measured glutathione (GSH) i...
#1Salvatore Sotgia (University of Sassari)H-Index: 25
#2Panagiotis Paliogiannis (University of Sassari)H-Index: 19
Last. Angelo Zinellu (University of Sassari)H-Index: 31
view all 10 authors...
The aim of this systematic review and meta-analysis was to assess the blood concentrations of the total and reduced forms of the low-molecular-weight antioxidant thiol glutathione (GSH) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. A literature search was conducted in the PubMed and Web of Science databases from inception until June 2020. In the 18 studies identified (involving a total of 974 COPD patients and 631 healthy controls), the pooled red...
2 CitationsSource
#1Francesca Silvagno (UNITO: University of Turin)H-Index: 19
#2Annamaria Vernone (UNITO: University of Turin)H-Index: 4
Last. Gianpiero Pescarmona (UNITO: University of Turin)H-Index: 43
view all 3 authors...
The novel COVID-19 pandemic is affecting the world’s population differently: mostly in the presence of conditions such as aging, diabetes and hypertension the virus triggers a lethal cytokine storm and patients die from acute respiratory distress syndrome, whereas in many cases the disease has a mild or even asymptomatic progression. A common denominator in all conditions associated with COVID-19 appears to be the impaired redox homeostasis responsible for reactive oxygen species (ROS) accumulat...
44 CitationsSource